Impact of Gluten-free Diet (GFD) on Some of Cardiovascular Risk Factors: a Systematic Review and Meta-analysis

Overview

Journal J Nutr Sci

Publisher Cambridge University Press

Specialty Nutritional Sciences

Date 2024 Sep 30

PMID 39345238

Authors

Pejman Rohani

Elma Izze da Silva Magalhaes

Roya Imanifard

Maryam Jarahzadeh

Fateme Ziamanesh

Somaye Fatahi

Hajar Ghorbani Jalalieh

Mohammad Hassan Sohouli

Affiliations

Soon will be listed here.

Abstract

A gluten-free diet (GFD) may have a stronger potential impact on reducing cardiovascular (CV) risk factors, according to research evidence. We investigated the impact of GFD on CV risk variables by doing a systematic review and meta-analysis for this reason. We conducted a thorough database search starting on January 1, 2000, and ending on July 12, 2022. We used random-effects models to pool the data. Totally 19 articles met the eligible criteria and were included. Pooled findings indicated that intervention with GFD has a significantly beneficial effect on high-density lipoprotein (HDL) (WMD: 4.80 mg/dl, 95% CI: 2.09, 7.51, = 0.001), systolic blood pressure (SBP) (WMD: -2.96 mmHg; 95% CI: -4.11, -1.81, < 0.001), and C-reactive protein (CRP) (WMD: -0.40, mg/l, 95% CI: -0.67, -0.14, = 0.002) levels. In celiac patients as well as with an intervention duration of more than 48 weeks, GFD increased TC and HDL compared to non-celiac patients and with an intervention duration lower than 48 weeks, respectively. The results of the present study showed that GFD can have a significant and beneficial effect on HDL, SBP, and CRP.

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