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Updates in Dermatomyositis: Newer Treatment Options and Outcome Measures From Dermatologic Perspectives

Overview
Journal Ann Dermatol
Specialty Dermatology
Date 2024 Sep 29
PMID 39343752
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Abstract

Dermatomyositis (DM) is a rare autoimmune connective tissue disease with characteristic skin manifestations and possible muscle involvement. Recent advances in classification system to include skin-predominant subtypes, understanding underlying pathogenic mechanisms and the relationship between clinical phenotypes and myositis-specific autoantibodies have led to development of novel therapeutic options. This corresponds with efforts to develop better outcome measures to accurately catch the patients' current disease status and treatment-induced improvements. This report will review the updates in newer treatments and outcome measures of DM, specifically from a dermatologic point of view.

References
1.
Ardeniz O, Unger S, Onay H, Ammann S, Keck C, Cianga C . β2-Microglobulin deficiency causes a complex immunodeficiency of the innate and adaptive immune system. J Allergy Clin Immunol. 2015; 136(2):392-401. DOI: 10.1016/j.jaci.2014.12.1937. View

2.
Pandya R, Dan J, Kleitsch J, White B, Werth V . Validation of Cutaneous Dermatomyositis Disease Area and Severity Index Activity Score and Other Efficacy Outcomes as Measures of Skin Disease in Dermatomyositis in the Lenabasum Phase 3 Trial. J Invest Dermatol. 2023; 143(12):2378-2385.e7. DOI: 10.1016/j.jid.2023.05.025. View

3.
Robinson E, Alves P, Bashir M, Zeidi M, Feng R, Werth V . Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro. J Invest Dermatol. 2017; 137(11):2445-2447. PMC: 5651184. DOI: 10.1016/j.jid.2017.05.035. View

4.
Ghazi E, Sontheimer R, Werth V . The importance of including amyopathic dermatomyositis in the idiopathic inflammatory myositis spectrum. Clin Exp Rheumatol. 2012; 31(1):128-34. PMC: 3883437. View

5.
Hansen R, Balthasar J . Intravenous immunoglobulin mediates an increase in anti-platelet antibody clearance via the FcRn receptor. Thromb Haemost. 2003; 88(6):898-9. View