Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2017 Jun 28

PMID 28652111

Citations 19

Authors

Elizabeth S Robinson

Paul Alves

Muhammad M Bashir

Majid Zeidi

Rui Feng

Victoria P Werth

Affiliations

Soon will be listed here.

Citing Articles

Geraniol modulates inflammatory and antioxidant pathways to mitigate intestinal ischemia-reperfusion injury in male rats.

Khoshnazar S, Mohagheghi M, Rahimi S, Dabiri S, Shahrokhi N, Shafieipour S Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 39841219 DOI: 10.1007/s00210-025-03802-y.

Long-Term Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: Follow-Up Data from a 3-Year Open-Label Extension Study.

Stone C, Ahuja G, Lopes Almeida Gomes L, Poroye J, Faden D, Xie L JID Innov. 2024; 5(1):100311.

PMID: 39403556 PMC: 11472610. DOI: 10.1016/j.xjidi.2024.100311.

Updates in Dermatomyositis: Newer Treatment Options and Outcome Measures From Dermatologic Perspectives.

Kim H, Werth V Ann Dermatol. 2024; 36(5):257-265.

PMID: 39343752 PMC: 11439981. DOI: 10.5021/ad.24.022.

Green Smoke, Red Flag: Cannabis and the Risk of Orbitopathy and Dermopathy in Thyrotoxicosis.

Okpujie V, Ozumba S, Olaomi O, Uwumiro F, Ajiboye A, Abesin O Cureus. 2023; 15(5):e39092.

PMID: 37378109 PMC: 10291966. DOI: 10.7759/cureus.39092.

Cannabidiol's neuroprotective properties and potential treatment of traumatic brain injuries.

Aychman M, Goldman D, Kaplan J Front Neurol. 2023; 14:1087011.

PMID: 36816569 PMC: 9932048. DOI: 10.3389/fneur.2023.1087011.

References

Tepper M, Zurier R, Burstein S . Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity. Bioorg Med Chem. 2014; 22(13):3245-51. DOI: 10.1016/j.bmc.2014.04.062. View

Zurier R, Sun Y, George K, Stebulis J, Rossetti R, Skulas A . Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4. FASEB J. 2009; 23(5):1503-9. PMC: 2669421. DOI: 10.1096/fj.08-118323. View

Bouaboula M, Rinaldi M, Carayon P, Carillon C, Delpech B, Shire D . Cannabinoid-receptor expression in human leukocytes. Eur J Biochem. 1993; 214(1):173-80. DOI: 10.1111/j.1432-1033.1993.tb17910.x. View

Munro S, Thomas K . Molecular characterization of a peripheral receptor for cannabinoids. Nature. 1993; 365(6441):61-5. DOI: 10.1038/365061a0. View

Stebulis J, Johnson D, Rossetti R, Burstein S, Zurier R . Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells. Life Sci. 2008; 83(19-20):666-70. DOI: 10.1016/j.lfs.2008.09.004. View

Zurier R, Rossetti R, Burstein S, Bidinger B . Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid. Biochem Pharmacol. 2003; 65(4):649-55. DOI: 10.1016/s0006-2952(02)01604-0. View

Pachman L, Hong D, Kinsella T, Mendez E, Kinder J, Chen E . TNFalpha-308A allele in juvenile dermatomyositis: association with increased production of tumor necrosis factor alpha, disease duration, and pathologic calcifications. Arthritis Rheum. 2000; 43(10):2368-77. DOI: 10.1002/1529-0131(200010)43:10<2368::AID-ANR26>3.0.CO;2-8. View

Nabatian A, Bashir M, Wysocka M, Sharma M, Werth V . Tumor necrosis factor α release in peripheral blood mononuclear cells of cutaneous lupus and dermatomyositis patients. Arthritis Res Ther. 2012; 14(1):R1. PMC: 3392787. DOI: 10.1186/ar3549. View

Kim J, Bashir M, Werth V . Gottron's papules exhibit dermal accumulation of CD44 variant 7 (CD44v7) and its binding partner osteopontin: a unique molecular signature. J Invest Dermatol. 2012; 132(7):1825-32. PMC: 3375388. DOI: 10.1038/jid.2012.54. View

10.

Parker J, Atez F, Rossetti R, Skulas A, Patel R, Zurier R . Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. Rheumatol Int. 2007; 28(7):631-5. DOI: 10.1007/s00296-007-0489-0. View

11.

Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R . Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol. 2011; 186(8):4794-804. DOI: 10.4049/jimmunol.1000702. View

12.

Bidinger B, Torres R, Rossetti R, Brown L, Beltre R, Burstein S . Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. Clin Immunol. 2003; 108(2):95-102. DOI: 10.1016/s1521-6616(03)00064-0. View