The Role of Single Nucleotide Polymorphisms in MicroRNA Genes in Head and Neck Squamous Cell Carcinomas: Susceptibility and Prognosis

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Sep 28

PMID 39336817

Authors

Elzbieta Szmida

Dorota Butkiewicz

Pawel Karpinski

Tomasz Rutkowski

Malgorzata Oczko-Wojciechowska

Maria Malgorzata Sasiadek

Affiliations

Soon will be listed here.

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide. The identification of molecular alterations adding to the individual risk of HNSCC development and progression is one of the most important challenges in studies on cancer genetics. MicroRNAs (miRNAs), which belong to the group of important post-transcriptional regulators of human gene expression, seem to be valuable options for consideration as key modifiers of individual cancer risk, and therefore may be helpful in predicting inter-individual differences in cancer risk, response to treatment and prognosis.

Methods: There have not been many studies focused on the relationship between miRNA variants and HNSCC published in PubMed within the last 15 years. We found and analyzed 30 reviews, meta-analyses and research papers and revealed 14 SNPs which have been reported as significant in the context of HNSCC susceptibility and/or prognosis.

Results: These 14 SNPs were located in 13 separate miRNAs. Among them, four were the most frequently studied (miRNA-146, -196, -149 and -499) and have been shown to have the greatest impact on the course of HNSCC. However, the presented results have been conflicting.

Conclusions: It must be concluded that, despite the years of studies, there are no conclusive reports demonstrating a significant role of SNPs in miRNAs in the context of the susceptibility to HNSCC or its prognosis.

References

Wang N, Li Y, Zhou R, Wang G, Wang C, Chen Z . Hsa-miR-196a2 functional SNP is associated with the risk of ESCC in individuals under 60 years old. Biomarkers. 2013; 19(1):43-8. DOI: 10.3109/1354750X.2013.866164. View

Wang B, Jiang L, Xu Q . A comprehensive evaluation for polymorphisms in family in cancer risk and prognosis: a system review and meta-analysis. Biosci Rep. 2018; 38(4). PMC: 6066660. DOI: 10.1042/BSR20180273. View

Wang A, Xu B, Tong N, Chen S, Yang Y, Zhang X . Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors. Genet Mol Res. 2012; 11(3):3051-62. DOI: 10.4238/2012.August.31.2. View

Bhaumik D, Scott G, Schokrpur S, Patil C, Campisi J, Benz C . Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene. 2008; 27(42):5643-7. PMC: 2811234. DOI: 10.1038/onc.2008.171. View

Roy R, De Sarkar N, Ghose S, Paul R, Pal M, Bhattacharya C . Genetic variations at microRNA and processing genes and risk of oral cancer. Tumour Biol. 2013; 35(4):3409-14. DOI: 10.1007/s13277-013-1450-3. View

Pan W, Wu C, Su Z, Duan Z, Li L, Mi F . Genetic polymorphisms of non-coding RNAs associated with increased head and neck cancer susceptibility: a systematic review and meta-analysis. Oncotarget. 2017; 8(37):62508-62523. PMC: 5617525. DOI: 10.18632/oncotarget.20096. View

Duan R, Pak C, Jin P . Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet. 2007; 16(9):1124-31. DOI: 10.1093/hmg/ddm062. View

Akhani A, Motaghi A, Sharif M, Hemati S . Association of the mir-499 polymorphisms with oral cavity and oropharyngeal squamous cell carcinoma in an Iranian population. Dent Res J (Isfahan). 2020; 17(3):174-178. PMC: 7386373. View

Wu C, Li M, Hu C, Duan H . Prognostic role of microRNA polymorphisms in patients with advanced esophageal squamous cell carcinoma receiving platinum-based chemotherapy. Cancer Chemother Pharmacol. 2013; 73(2):335-41. DOI: 10.1007/s00280-013-2364-x. View

10.

Wang J, Jiao J, Li Q, Long B, Wang K, Liu J . miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med. 2010; 17(1):71-8. DOI: 10.1038/nm.2282. View

11.

Hung P, Liu C, Chou C, Kao S, Yang C, Chang K . miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes. PLoS One. 2013; 8(11):e79926. PMC: 3841223. DOI: 10.1371/journal.pone.0079926. View

12.

Hao X, Xia L, Qu R, Yang X, Jiang M, Zhou B . Association between miR-146a rs2910164 polymorphism and specific cancer susceptibility: an updated meta-analysis. Fam Cancer. 2017; 17(3):459-468. DOI: 10.1007/s10689-017-0056-0. View

13.

Sexton G, Walsh P, Moriarty F, ONeill J . The changing face of Irish head and neck cancer epidemiology: 20 years of data. Eur Arch Otorhinolaryngol. 2021; 279(6):3079-3088. PMC: 9072499. DOI: 10.1007/s00405-021-07118-4. View

14.

Sun D, Zhang X, Zhang X . C/G polymorphism increased the risk of head and neck cancer, but overall cancer risk: an analysis of 89 studies. Biosci Rep. 2017; 38(1). PMC: 6435476. DOI: 10.1042/BSR20171342. View

15.

Rusca N, Monticelli S . MiR-146a in Immunity and Disease. Mol Biol Int. 2011; 2011:437301. PMC: 3200075. DOI: 10.4061/2011/437301. View

16.

Wilkins O, Titus A, Gui J, Eliot M, Butler R, Sturgis E . Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma. Carcinogenesis. 2017; 38(10):986-993. PMC: 5862295. DOI: 10.1093/carcin/bgx056. View

17.

Tandon D, Dewangan J, Srivastava S, Garg V, Rath S . miRNA genetic variants: As potential diagnostic biomarkers for oral cancer. Pathol Res Pract. 2017; 214(2):281-289. DOI: 10.1016/j.prp.2017.10.002. View

18.

Toraih E, Fawzy M, Mohammed E, Hussein M, El-Labban M . MicroRNA-196a2 Biomarker and Targetome Network Analysis in Solid Tumors. Mol Diagn Ther. 2016; 20(6):559-577. DOI: 10.1007/s40291-016-0223-2. View

19.

Chhichholiya Y, Suryan A, Suman P, Munshi A, Singh S . SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes. Front Genet. 2021; 12:793523. PMC: 8673831. DOI: 10.3389/fgene.2021.793523. View

20.

Guo X, Zhao L, Shen Y, Shao Y, Wei W, Liu F . Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis. Onco Targets Ther. 2019; 12:3565-3580. PMC: 6537464. DOI: 10.2147/OTT.S193958. View