A Comprehensive Evaluation for Polymorphisms in Family in Cancer Risk and Prognosis: a System Review and Meta-analysis

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 May 3

PMID 29717029

Citations 10

Authors

Ben-Gang Wang

Li-Yue Jiang

Qian Xu

Affiliations

Soon will be listed here.

Abstract

miRNA polymorphisms had potential to be biomarkers for cancer susceptibility and prognosis. The mature family was considered as the most important miRNA for the cancer incidence and progression. Recently, the promising miRNAs were reported to be associated with various cancers, but the results were inconsistent. We performed a first-reported systematic review with a meta-analysis for the association of family single nucleotide polymorphisms (SNPs) with cancer risk/prognosis. Ten studies were included with a total of 3878 cancer cases and 4725 controls for the risk study and 1665 cancer patients for the prognosis study in this meta-analysis. In the risk study, the rs10877887 and rs13293512 were shown no significant association for the overall cancer risk. In the stratified analysis, the rs10877887 variant genotype was significantly associated with a decreased cancer risk in head and neck cancer (TC compared with TT: =0.017; odds ratio (OR) = 0.81; TC + CC compared with TT: =0.020; OR = 0.82). In the prognosis study, the let-7i rs10877887 SNP was shown to be associated with a higher risk for cancer prognosis in the dominate model (=0.004; hazard ratio (HR) = 1.32). The other two SNPs ( rs10739971 and rs629367) were not found to be associated with cancer survival. None of the family polymorphisms had potential to be biomarkers for cancer susceptibility but rs10877887 SNP had potential to be predicting markers for cancer prognosis. In the future, large-sample studies are still needed to verify our findings.

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