Involvement of a Battery of Investigated Genes in Lipid Droplet Pathophysiology and Associated Comorbidities

Overview

Journal Adipocyte

Specialties Cell Biology
Endocrinology
Physiology

Date 2024 Sep 27

PMID 39329369

Authors

Sami N Al Harake

Yasamin Abedin

Fatema Hatoum

Nour Zahraa Nassar

Ali Ali

Aline Nassar

Amjad Kanaan

Samer Bazzi

Sami Azar

Frederic Harb

Hilda E Ghadieh

Affiliations

Soon will be listed here.

Abstract

Lipid droplets (LDs) are highly specialized energy storage organelles involved in the maintenance of lipid homoeostasis by regulating lipid flux within white adipose tissue (WAT). The physiological function of adipocytes and LDs can be compromised by mutations in several genes, leading to NEFA-induced lipotoxicity, which ultimately manifests as metabolic complications, predominantly in the form of dyslipidemia, ectopic fat accumulation, and insulin resistance. In this review, we delineate the effects of mutations and deficiencies in genes - , , , , , , , , , and - involved in lipid droplet metabolism and their associated pathophysiological impairments, highlighting their roles in the development of lipodystrophies and metabolic dysfunction.

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