Antimicrobial Resistance and Genomic Analysis of Isolates from Foodborne Outbreaks, Huzhou, China, 2019-2023

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Sep 26

PMID 39323890

Authors

Wei Yan

Lei Ji

Fenfen Dong

Liping Chen

Rui Yuan

Peng Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this study was to investigate the epidemiological and genomic characteristics of () isolates from outbreaks in Huzhou, China.

Methods: This study aims to analyze the epidemiological data on outbreaks reported in Huzhou from 2019 to 2023. A total of 70 outbreak isolates were collected. The antibiotic resistance, serotypes, molecular typing, and genomic characteristics of these isolates were analyzed.

Results: Most outbreaks of infection occurred in the summer, and the majority of outbreaks occurred in restaurants and rural banquets. High resistance rates were observed for ampicillin (AMP, 24.29%), followed by tetracycline (TET, 15.71%) and trimethoprim-sulfamethoxazole (SXT, 15.71%). The newly emerged serotype O10:K4 became dominant from 2021 to 2023, with most isolates belonging to ST3. The resistance gene was frequently detected among these isolates. The pulsed-field gel electrophoresis (PFGE) and whole-genome single-nucleotide polymorphisms (wgSNPs) effectively differentiated the nine outbreaks.

Conclusion: The newly emerged serotype O10:K4 became dominant from 2021 to 2023, with most isolates being ST3. PFGE and WGS technologies provided reliable methods for typing and identifying for outbreaks.

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