Recent Advancements in Nanopharmaceuticals for Novel Drug Delivery Systems

Overview

Journal Pharm Nanotechnol

Specialties Biotechnology
Pharmacology

Date 2024 Sep 26

PMID 39323341

Authors

Kai Bin Liew

Ee Va Koh

Xue Er Kong

Nurdina Aleyah Ismail

Rabiatul Adawiyah Abu Bakar

Phei Er Kee

Syed Haroon Khalid

Hiu Ching Phang

Hiu Ching Haroon Phang

Affiliations

Soon will be listed here.

Abstract

Nanoparticles have found applications across diverse sectors, including agriculture, food, cosmetics, chemicals, mechanical engineering, automotive, and oil and gas industries. In the medical field, nanoparticles have garnered considerable attention due to their great surface area, high solubility, rapid dissolution, and enhanced bioavailability. Nanopharmaceuticals are specifically designed to precisely deliver drug substances to targeted tissues and cells, aiming to optimize therapeutic efficacy while minimizing potential adverse effects. Furthermore, nanopharmaceuticals offer advantages, such as expedited therapeutic onset, reduced dosages, minimized variability between fed and fasted states, and enhanced patient compliance. The increasing interest in nanopharmaceuticals research among scientists and industry stakeholders highlights their potential for various medical applications from disease management to cancer treatment. This review examines the distinctive characteristics of ideal nanoparticles for efficient drug delivery, explores the current types of nanoparticles utilized in medicine, and delves into the applications of nanopharmaceuticals, including drug and gene delivery, as well as transdermal drug administration. This review provides insights into the nanopharmaceuticals field, contributing to the development of novel drug delivery systems and enhancing the potential of nanotechnology in healthcare.

References

Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F . The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine. Molecules. 2020; 25(1). PMC: 6982820. DOI: 10.3390/molecules25010112. View

Weissig V, Pettinger T, Murdock N . Nanopharmaceuticals (part 1): products on the market. Int J Nanomedicine. 2014; 9:4357-73. PMC: 4172146. DOI: 10.2147/IJN.S46900. View

Malik S, Muhammad K, Waheed Y . Nanotechnology: A Revolution in Modern Industry. Molecules. 2023; 28(2). PMC: 9865684. DOI: 10.3390/molecules28020661. View

Patra J, Das G, Fraceto L, Campos E, Del Pilar Rodriguez-Torres M, Acosta-Torres L . Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018; 16(1):71. PMC: 6145203. DOI: 10.1186/s12951-018-0392-8. View

Liu L, Ye Q, Lu M, Lo Y, Hsu Y, Wei M . A new approach to reduce toxicities and to improve bioavailabilities of platinum-containing anti-cancer nanodrugs. Sci Rep. 2015; 5:10881. PMC: 4454134. DOI: 10.1038/srep10881. View

Soares S, Sousa J, Pais A, Vitorino C . Nanomedicine: Principles, Properties, and Regulatory Issues. Front Chem. 2018; 6:360. PMC: 6109690. DOI: 10.3389/fchem.2018.00360. View

Yusuf A, Almotairy A, Henidi H, Alshehri O, Aldughaim M . Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles' Physicochemical Properties on Responses in Biological Systems. Polymers (Basel). 2023; 15(7). PMC: 10096782. DOI: 10.3390/polym15071596. View

Al-Kassas R, Bansal M, Shaw J . Nanosizing techniques for improving bioavailability of drugs. J Control Release. 2017; 260:202-212. DOI: 10.1016/j.jconrel.2017.06.003. View

Wang Y, Pi C, Feng X, Hou Y, Zhao L, Wei Y . The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs. Int J Nanomedicine. 2020; 15:6295-6310. PMC: 7455773. DOI: 10.2147/IJN.S257269. View

10.

Naseri N, Ajorlou E, Asghari F, Pilehvar-Soltanahmadi Y . An update on nanoparticle-based contrast agents in medical imaging. Artif Cells Nanomed Biotechnol. 2017; 46(6):1111-1121. DOI: 10.1080/21691401.2017.1379014. View

11.

Farjadian F, Ghasemi A, Gohari O, Roointan A, Karimi M, Hamblin M . Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities. Nanomedicine (Lond). 2018; 14(1):93-126. PMC: 6391637. DOI: 10.2217/nnm-2018-0120. View

12.

Muringayil Joseph T, Mahapatra D, Esmaeili A, Piszczyk L, Hasanin M, Kattali M . Nanoparticles: Taking a Unique Position in Medicine. Nanomaterials (Basel). 2023; 13(3). PMC: 9920911. DOI: 10.3390/nano13030574. View

13.

Banerjee A, Qi J, Gogoi R, Wong J, Mitragotri S . Role of nanoparticle size, shape and surface chemistry in oral drug delivery. J Control Release. 2016; 238:176-185. PMC: 5289391. DOI: 10.1016/j.jconrel.2016.07.051. View

14.

Rizvi S, Saleh A . Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J. 2018; 26(1):64-70. PMC: 5783816. DOI: 10.1016/j.jsps.2017.10.012. View

15.

Heuer-Jungemann A, Feliu N, Bakaimi I, Hamaly M, AlKilany A, Chakraborty I . The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles. Chem Rev. 2019; 119(8):4819-4880. DOI: 10.1021/acs.chemrev.8b00733. View

16.

Szeto G, Lavik E . Materials design at the interface of nanoparticles and innate immunity. J Mater Chem B. 2016; 4(9):1610-1618. PMC: 4950994. DOI: 10.1039/C5TB01825K. View

17.

Di J, Gao X, Du Y, Zhang H, Gao J, Zheng A . Size, shape, charge and "stealthy" surface: Carrier properties affect the drug circulation time . Asian J Pharm Sci. 2021; 16(4):444-458. PMC: 8520042. DOI: 10.1016/j.ajps.2020.07.005. View

18.

Suk J, Xu Q, Kim N, Hanes J, Ensign L . PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv Drug Deliv Rev. 2015; 99(Pt A):28-51. PMC: 4798869. DOI: 10.1016/j.addr.2015.09.012. View

19.

Clogston J, Patri A . Zeta potential measurement. Methods Mol Biol. 2010; 697:63-70. DOI: 10.1007/978-1-60327-198-1_6. View

20.

Awashra M, Mlynarz P . The toxicity of nanoparticles and their interaction with cells: an metabolomic perspective. Nanoscale Adv. 2023; 5(10):2674-2723. PMC: 10186990. DOI: 10.1039/d2na00534d. View