Loss of SELENOW Aggravates Muscle Loss with Regulation of Protein Synthesis and the Ubiquitin-proteasome System

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2024 Sep 20

PMID 39303039

Authors

Jia-Cheng Yang

Meng Liu

Rong-Hui Huang

Ling Zhao

Qin-Jian Niu

Ze-Jing Xu

Jin-Tao Wei

Xin Gen Lei

Lv-Hui Sun

Affiliations

Soon will be listed here.

Abstract

Sarcopenia is characterized by accelerated muscle mass and function loss, which burdens and challenges public health worldwide. Several studies indicated that selenium deficiency is associated with sarcopenia; however, the specific mechanism remains unclear. Here, we demonstrated that selenoprotein W (SELENOW) containing selenium in the form of selenocysteine functioned in sarcopenia. SELENOW expression is up-regulated in dexamethasone (DEX)-induced muscle atrophy and age-related sarcopenia mouse models. Knockout (KO) of SELENOW profoundly aggravated the process of muscle mass loss in the two mouse models. Mechanistically, KO suppressed the RAC1-mTOR cascade by the interaction between SELENOW and RAC1 and induced the imbalance of protein synthesis and degradation. Consistently, overexpression of SELENOW in vivo and in vitro alleviated the muscle and myotube atrophy induced by DEX. SELENOW played a role in age-related sarcopenia and regulated the genes associated with aging. Together, our study uncovered the function of SELENOW in age-related sarcopenia and provides promising evidence for the prevention and treatment of sarcopenia.

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