The MTOR Pathway in the Control of Protein Synthesis

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2006 Sep 23

PMID 16990457

Citations 316

Authors

Xuemin Wang

Christopher G Proud

Affiliations

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Abstract

Signaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.

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