Multiple Sclerosis: Free Light Chains in Cerebrospinal Fluid

Overview

Journal Neurology

Specialty Neurology

Date 1985 Oct 1

PMID 3929159

Citations 14

Authors

R A Rudick

D R Peter

J M Bidlack

D W Knutson

Affiliations

Soon will be listed here.

Abstract

We found free light chains in the CSF of 18 MS patients, but not in any of 14 patients with other neurologic disease. CSF from all MS patients contained kappa and lambda chain dimers, less frequently contained light chain monomers, and never contained free gamma heavy chains. Light chains were not detected in matched serum samples. CSF from MS patients did not release free light chains from whole IgG in CSF of controls. The findings suggest that these free light chains originate in plasma cells, not from degradation of whole IgG.

Citing Articles

Novel CSF Biomarkers Tracking Autoimmune Inflammatory and Neurodegenerative Aspects of CNS Diseases.

Kapaki E, Vakrakou A, Boufidou F Diagnostics (Basel). 2023; 13(1).

PMID: 36611365 PMC: 9818715. DOI: 10.3390/diagnostics13010073.

Intrathecal B cell-related markers for an optimized biological investigation of multiple sclerosis patients.

Feki S, Damak M, Sakka S, Ben Ali Y, Mejdoub S, Bouattour N Sci Rep. 2022; 12(1):16425.

PMID: 36180495 PMC: 9525661. DOI: 10.1038/s41598-022-19811-3.

The Increasing Role of Kappa Free Light Chains in the Diagnosis of Multiple Sclerosis.

Konen F, Schwenkenbecher P, Jendretzky K, Gingele S, Suhs K, Tumani H Cells. 2021; 10(11).

PMID: 34831279 PMC: 8622045. DOI: 10.3390/cells10113056.

Evaluation of Kappa Index as a Tool in the Diagnosis of Multiple Sclerosis: Implementation in Routine Screening Procedure.

Sanz Diaz C, de Las Heras Florez S, Perez M, Hernandez Perez M, Martin Garcia V Front Neurol. 2021; 12:676527.

PMID: 34456842 PMC: 8386692. DOI: 10.3389/fneur.2021.676527.

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

Leurs C, Twaalfhoven H, Lissenberg-Witte B, van Pesch V, Dujmovic I, Drulovic J Mult Scler. 2019; 26(8):912-923.

PMID: 31066634 PMC: 7350201. DOI: 10.1177/1352458519845844.