Treatment with Aldose Reductase Inhibitor or with Myo-inositol Arrests Deterioration of the Electroretinogram of Diabetic Rats

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1985 Aug 1

PMID 3928685

Citations 15

Authors

L C MacGregor

F M Matschinsky

Affiliations

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Abstract

Biochemical abnormalities in the retinal pigment epithelium of experimentally diabetic animals include increased sorbitol and decreased myo-inositol. Diabetes also causes a progressive reduction in the amplitude of the c-wave of the electroretinogram of the pigmented rat. The c-wave is generated by the retinal pigmented epithelium. Myo-inositol administration or treatment with sorbinil, an inhibitor of aldose reductase, arrested the decline in the c-wave. Therefore, hyperglycemia-associated defects in myo-inositol or sorbitol metabolism may be involved in the pathogenesis of the electrophysiological deficit of the diabetic retina. The homogeneous cell layer of the pigment epithelium may be a useful tissue model for studying the pathogenesis of the complications of diabetes.

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