Antioxidant Enzyme Prdx1 Inhibits Osteoclastogenesis Via Suppressing ROS and NFATc1 Signaling Pathways

Overview

Journal J Cell Physiol

Specialties Cell Biology
Physiology

Date 2024 Sep 12

PMID 39263840

Authors

Chao Wang

Gang Wang

Fangming Song

Jinmin Zhao

Qian Liu

Jiake Xu

Affiliations

Soon will be listed here.

Abstract

Bone is a dynamic organ which continuously undergoes remodeling throughout one's lifetime. Cellular production of reactive oxygen species (ROS) is essential for regulating bone homeostasis. Osteoclasts, multinucleated giant cells differentiated from macrophage lineage, are responsible for osteolytic bone conditions which are closely linked to ROS signaling pathways. In this study, an anti-ROS enzyme, peroxiredoxin 1 (Prdx1) was found to be expressed both in bone marrow macrophages and osteoclasts. Recombinant Prdx1 protein was found to dose-dependently inhibit ROS production and osteoclast differentiation. Mechanistically, Prdx1 protein also attenuated NFATc1 activation as well as the expression of C-Fos, V-ATPase-d2, Cathepsin K, and Integrin αV. Collectively, Prdx1 is a negative regulator on osteoclast formation via inhibiting RANKL-mediated ROS activity, thus suggesting its potential application for treating osteoclast related disorders.

Citing Articles

Antioxidant enzyme Prdx1 inhibits osteoclastogenesis via suppressing ROS and NFATc1 signaling pathways.

Wang C, Wang G, Song F, Zhao J, Liu Q, Xu J J Cell Physiol. 2024; 239(12):e31431.

PMID: 39263840 PMC: 11649962. DOI: 10.1002/jcp.31431.

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