The Importance of Psychotherapy for Treatment-Resistant Depression

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2024 Sep 11

PMID 39261433

Authors

Dham Ho

Yong-Ku Kim

Weon-Jeong Lim

Affiliations

Soon will be listed here.

Abstract

Many clinicians choose psychoanalytic psychotherapy or supportive psychotherapy as the primary method of treating depression with or without antidepressant medications. Despite new antidepressants, 20% or more patients showed inadequate responses to the medications, and remained in chronic courses, known as "treatment-resistant depression (TRD)."In this chapter, we described (1) the reasons for psychotherapy in treating TRD from the perspectives of the hazard of polypharmacy, resistance, and neural mechanisms. (2) Next, we focused on the importance of assessment with two clinical vignettes and the original modality of psychoanalysis, psychoanalytic psychotherapy, and supportive psychotherapy in brief. (3) Finally, we described specific considerations in undertaking psychotherapy for TRD patients in terms of transference, countertransference, and resistance. In addition, the efficacy of psychoanalytic psychotherapy in childhood, adolescent, and late-life depression has been depicted in this paper.

References

Barrett L, Tugade M, Engle R . Individual differences in working memory capacity and dual-process theories of the mind. Psychol Bull. 2004; 130(4):553-73. PMC: 1351135. DOI: 10.1037/0033-2909.130.4.553. View

Beekman A, Copeland J, Prince M . Review of community prevalence of depression in later life. Br J Psychiatry. 1999; 174:307-11. DOI: 10.1192/bjp.174.4.307. View

Beekman A, Geerlings S, Deeg D, Smit J, Schoevers R, de Beurs E . The natural history of late-life depression: a 6-year prospective study in the community. Arch Gen Psychiatry. 2002; 59(7):605-11. DOI: 10.1001/archpsyc.59.7.605. View

Birmaher B, Ryan N, Williamson D, Brent D, Kaufman J, Dahl R . Childhood and adolescent depression: a review of the past 10 years. Part I. J Am Acad Child Adolesc Psychiatry. 1996; 35(11):1427-39. DOI: 10.1097/00004583-199611000-00011. View

Brown G, Ten Have T, Henriques G, Xie S, Hollander J, Beck A . Cognitive therapy for the prevention of suicide attempts: a randomized controlled trial. JAMA. 2005; 294(5):563-70. DOI: 10.1001/jama.294.5.563. View

Burrows G, Norman T, Judd F . Definition and differential diagnosis of treatment-resistant depression. Int Clin Psychopharmacol. 1994; 9 Suppl 2:5-10. DOI: 10.1097/00004850-199406002-00002. View

Chambless D, Hollon S . Defining empirically supported therapies. J Consult Clin Psychol. 1998; 66(1):7-18. DOI: 10.1037//0022-006x.66.1.7. View

Conner K, Duberstein P, Conwell Y, Seidlitz L, Caine E . Psychological vulnerability to completed suicide: a review of empirical studies. Suicide Life Threat Behav. 2002; 31(4):367-85. DOI: 10.1521/suli.31.4.367.22048. View

Cuijpers P . Minimising interventions in the treatment and prevention of depression. Taking the consequences of the 'Dodo Bird Verdict'. J Ment Health. 2017; 7(4):355-365. DOI: 10.1080/09638239817950. View

10.

Cuijpers P, Schoevers R . Increased mortality in depressive disorders: a review. Curr Psychiatry Rep. 2004; 6(6):430-7. DOI: 10.1007/s11920-004-0007-y. View

11.

Cuijpers P, van Straten A, Smit F . Psychological treatment of late-life depression: a meta-analysis of randomized controlled trials. Int J Geriatr Psychiatry. 2006; 21(12):1139-49. DOI: 10.1002/gps.1620. View

12.

Cuijpers P, van Straten A, Andersson G, van Oppen P . Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. J Consult Clin Psychol. 2008; 76(6):909-22. DOI: 10.1037/a0013075. View

13.

Cuijpers P, de Beurs D, van Spijker B, Berking M, Andersson G, Kerkhof A . The effects of psychotherapy for adult depression on suicidality and hopelessness: a systematic review and meta-analysis. J Affect Disord. 2012; 144(3):183-90. DOI: 10.1016/j.jad.2012.06.025. View

14.

Cuijpers P, Karyotaki E, Eckshtain D, Ng M, Corteselli K, Noma H . Psychotherapy for Depression Across Different Age Groups: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2020; 77(7):694-702. PMC: 7081149. DOI: 10.1001/jamapsychiatry.2020.0164. View

15.

DeRubeis R, Siegle G, Hollon S . Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms. Nat Rev Neurosci. 2008; 9(10):788-96. PMC: 2748674. DOI: 10.1038/nrn2345. View

16.

Etkin A, Pittenger C, Polan H, Kandel E . Toward a neurobiology of psychotherapy: basic science and clinical applications. J Neuropsychiatry Clin Neurosci. 2005; 17(2):145-58. DOI: 10.1176/jnp.17.2.145. View

17.

Fava M . Diagnosis and definition of treatment-resistant depression. Biol Psychiatry. 2003; 53(8):649-59. DOI: 10.1016/s0006-3223(03)00231-2. View

18.

Gore F, Bloem P, Patton G, Ferguson J, Joseph V, Coffey C . Global burden of disease in young people aged 10-24 years: a systematic analysis. Lancet. 2011; 377(9783):2093-102. DOI: 10.1016/S0140-6736(11)60512-6. View

19.

Gunlicks-Stoessel M, Mufson L, Jekal A, Turner J . The impact of perceived interpersonal functioning on treatment for adolescent depression: IPT-A versus treatment as usual in school-based health clinics. J Consult Clin Psychol. 2010; 78(2):260-7. PMC: 2853239. DOI: 10.1037/a0018935. View

20.

Hariri A, Bookheimer S, Mazziotta J . Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport. 2000; 11(1):43-8. DOI: 10.1097/00001756-200001170-00009. View