Application of Neutrophil to Lymphocyte Ratio in Ankylosing Spondylitis: Based on Bibliometric and Visualization Analysis

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2024 Sep 11

PMID 39259110

Authors

Cong Chengzhi

Liu Jian

Hu Yuedi

Li Yang

Chen Yiming

Huang Dan

Affiliations

Soon will be listed here.

Abstract

Ankylosing spondylitis (AS) as a autoimmune disease involves inflammatory responses in the development of the disease, often causing changes in the neutrophil to lymphocyte ratio (NLR). In the past few decades, research on the relationship between NLR and AS has generally shown an upward trend. This study adopts the bibliometrics method to analyze the development trend, frontier, and hotspots of global research in this field in the past 2 decades. By searching for publications in the SCI-Expanded edition of the Web of Science Core Collection, the information of literature published between 2000 and 2023 is recorded. Based on the VOSviewer, CiteSpace and Excel, bibliometric analysis, and visualization analysis are conducted on the overall distribution of annual output, leading countries, active institutions, journals, authors, co-cited references, and keywords. Through retrieving and screening, a total of 1654 papers are obtained for analysis. In the past 2 decades, the number of publications related to this field has shown an increasing trend. The United States has the highest Hirsch index (H-index) and publication volume. The most productive institution is Harvard University, while the H-index of the University of Milan in Italy is far ahead. Frontiers in Immunology is the institution with the highest output. The H-index of the Annals of the Rheumatic holds the top position. This study has uncovered the main emphasis on NLR in AS research and has provided clarification regarding the value of NLR as a biomarker for immune inflammatory response in the diagnosis and prognosis of AS.

References

Pisco C, Pedro T, Aires A, Fonseca L, Fonseca S, Castro P . The effect of neutrophil-to-lymphocyte ratio and systemic inflammatory response on perihematomal edema after intracerebral hemorrhage. J Clin Neurosci. 2023; 115:33-37. DOI: 10.1016/j.jocn.2023.07.008. View

Synnestvedt M, Chen C, Holmes J . CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc. 2006; :724-8. PMC: 1560567. View

Peng S, Xia Y, Wang Y, Yu X, Wu Z, Zhang L . Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: a bibliometric and visualized analysis. Front Pharmacol. 2023; 14:1220418. PMC: 10552780. DOI: 10.3389/fphar.2023.1220418. View

Mercan R, Bitik B, Tufan A, Bozbulut U, Atas N, Ozturk M . The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis. J Clin Lab Anal. 2015; 30(5):597-601. PMC: 6807125. DOI: 10.1002/jcla.21908. View

Marx A, Kallert S, Brunner T, Villegas J, Geier F, Fixemer J . The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1 CD8 T cells in chronic viral infection. Immunity. 2023; 56(4):813-828.e10. DOI: 10.1016/j.immuni.2023.01.029. View

Wang C, Liao Q, Hu Y, Zhong D . T lymphocyte subset imbalances in patients contribute to ankylosing spondylitis. Exp Ther Med. 2014; 9(1):250-256. PMC: 4247318. DOI: 10.3892/etm.2014.2046. View

Kavazovic I, Dimitropoulos C, Gasparini D, Roncevic Filipovic M, Barkovic I, Koster J . Vaccination provides superior in vivo recall capacity of SARS-CoV-2-specific memory CD8 T cells. Cell Rep. 2023; 42(4):112395. PMC: 10070771. DOI: 10.1016/j.celrep.2023.112395. View

Xu S, Ma Y, Wu M, Zhang X, Yang J, Deng J . Neutrophil lymphocyte ratio in patients with ankylosing spondylitis: A systematic review and meta-analysis. Mod Rheumatol. 2019; 30(1):141-148. DOI: 10.1080/14397595.2018.1564165. View

De Cassai A, Torrano V, Pistollato E, Monteleone F, Tinti G, Volpe F . Impact of self-citation on author h-index in anaesthesiology and pain medicine. Br J Anaesth. 2023; 131(6):e195-e196. DOI: 10.1016/j.bja.2023.09.017. View

10.

Garg K, Rafiq R, Mishra S, Singh P, Agrawal D, Chandra P . Cervical Spine Fracture with Extreme Dislocation in a Patient with Ankylosing Spondylitis: A Case Report and Systematic Review of the Literature. Neurol India. 2022; 70(Supplement):S296-S301. DOI: 10.4103/0028-3886.360906. View

11.

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss D . Neutrophil extracellular traps kill bacteria. Science. 2004; 303(5663):1532-5. DOI: 10.1126/science.1092385. View

12.

Lee H, Kim Y, Kim G, Ahn E, So M, Sohn D . Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as predictors of 12-week treatment response and drug persistence of anti-tumor necrosis factor-α agents in patients with rheumatoid arthritis: a retrospective chart review analysis. Rheumatol Int. 2019; 39(5):859-868. DOI: 10.1007/s00296-019-04276-x. View

13.

Yang J, Xu S, Chen M, Yuan Y, Zhang X, Ma Y . Serum Sclerostin and Bone Morphogenetic Protein-2 Levels in Patients with Ankylosing Spondylitis: A Meta-Analysis. Calcif Tissue Int. 2019; 105(1):37-50. DOI: 10.1007/s00223-019-00542-z. View

14.

Liu L, Hu X . Predictive values of circulating miR-146a and miR-155 for disease activity and clinical response to TNF-α blocking therapy in patients with ankylosing spondylitis. Int J Rheum Dis. 2023; 27(1):e15004. DOI: 10.1111/1756-185X.15004. View

15.

Soulard J, Vuillerme N, Vaillant J . Gait Characteristics in Patients With Ankylosing Spondylitis: Protocol for a Systematic Review. JMIR Res Protoc. 2019; 8(5):e12470. PMC: 6658243. DOI: 10.2196/12470. View

16.

Han L, Lv Q, Guo K, Li L, Zhang H, Bian H . Th17 cell-derived miR-155-5p modulates interleukin-17 and suppressor of cytokines signaling 1 expression during the progression of systemic sclerosis. J Clin Lab Anal. 2022; 36(6):e24489. PMC: 9169208. DOI: 10.1002/jcla.24489. View

17.

Roldan-Valadez E, Salazar-Ruiz S, Ibarra-Contreras R, Rios C . Current concepts on bibliometrics: a brief review about impact factor, Eigenfactor score, CiteScore, SCImago Journal Rank, Source-Normalised Impact per Paper, H-index, and alternative metrics. Ir J Med Sci. 2018; 188(3):939-951. DOI: 10.1007/s11845-018-1936-5. View

18.

Yao R, Ren C, Wang J, Wu G, Zhu X, Xia Z . Publication Trends of Research on Sepsis and Host Immune Response during 1999-2019: A 20-year Bibliometric Analysis. Int J Biol Sci. 2020; 16(1):27-37. PMC: 6930382. DOI: 10.7150/ijbs.37496. View

19.

Papachristodoulou E, Kakoullis L, Christophi C, Psarelis S, Hajiroussos V, Parperis K . The relationship of neutrophil-to-lymphocyte ratio with health-related quality of life, depression, and disease activity in SLE: a cross-sectional study. Rheumatol Int. 2023; 43(10):1841-1848. PMC: 10435585. DOI: 10.1007/s00296-023-05381-8. View

20.

Xu S, Zhang X, Ma Y, Chen Y, Xie H, Yu L . FOXO3a Alleviates the Inflammation and Oxidative Stress Regulating TGF-β and HO-1 in Ankylosing Spondylitis. Front Immunol. 2022; 13:935534. PMC: 9247177. DOI: 10.3389/fimmu.2022.935534. View