A Pan-cancer Analysis Of Wnt Family Member 7B in Human Cancers

Overview

Journal Cancer Innov

Specialty Biomedical Engineering

Date 2024 Sep 11

PMID 39257440

Authors

Rui Wang

Ni-Sha Wu

Li Wang

Zhi-Zhao Zhang

Cheng-Fang Wang

Yan Wang

Yan Liang

Yi Zhang

Xiao-Wei Qi

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have highlighted the crucial role of in the development of various cancers, including breast, pancreatic, and gastric cancers. However, research into the involvement of is often confined to specific tumor types, with a noticeable lack of comprehensive studies spanning multiple cancer forms. The potential of as a diagnostic or prognostic cancer biomarker has not been fully explored.

Methods: In this study, we combined bioinformatics and immunohistochemistry analyses to examine the expression patterns and functions of in cancerous and adjacent noncancerous tissues across a range of tumors.

Results: Our data indicate that may serve as a novel prognostic biomarker and therapeutic target in certain cancers.

Conclusion: We found significant upregulation of expression levels in the majority of cancer cases examined. Furthermore, can influence cancer prognosis by modulating the tumor microenvironment, immune cell infiltration, and tumor stemness, among other factors. Additionally, we examined the associations between anticancer drug sensitivity and expression, which could aid in the development of more precise clinical therapies.

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