Relationship Between NLR and Penile Squamous Cell Carcinoma: a Systematic Review and Meta-analysis

Overview

Journal BMC Urol

Publisher Biomed Central

Specialty Urology

Date 2024 Sep 6

PMID 39243079

Authors

Saghar Babadi

Matin Moallem Shahri

Sima Foroughi Nematollahi

Arnav Barpujari

Alec Clark

Brandon Lucke-Wold

Shirin Sarejloo

Arshin Ghaedi

Aida Bazrgar

Shokoufeh Khanzadeh

Affiliations

Soon will be listed here.

Abstract

Objective: We conducted this study to summarize the results of studies reporting the role of NLR (neutrophil to lymphocyte ratio) in PSCC (penile squamous cell carcinoma).

Methods: This meta-analysis was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. A systematic search was conducted on PubMed, Scopus, and web of science up to March 10, 2023. Fourteen studies were included in the review. The NOS (Newcastle-Ottawa Scale) was used to determine the quality of the included studies. This meta-analysis was conducted on the studies reporting the relationship between NLR and survival using HR (hazard ratio) and 95% CI (confidence interval).

Results: There was a significant association between NLR levels and the prognosis, nodal stage, and anatomical tumor stage of PSCC patients. In the meta-analysis of the association of NLR with survival, NLR level was significantly associated with lower cancer-specific survival (HR = 3.51, 95% CI = 2.07-5.98, p < 0.001) and lower disease-free survival (HR = 2.88, 95% CI = 1.60-5.20, p < 0.001). However, NLR was found to have no association with the stage, grade, location, and size of the tumor.

Conclusion: NLR has a significant diagnostic and prognostic value in PSCC.

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