Investigating the Effects of Ginkgo Biloba Leaf Extract on Cognitive Function in Alzheimer's Disease

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2024 Sep 5

PMID 39238068

Authors

Cheng Zhu

Jie Liu

Jixin Lin

Jiaxi Xu

Enyan Yu

Affiliations

Soon will be listed here.

Abstract

Aims: Alzheimer's disease (AD) is a neurodegenerative disorder with limited treatment options. This study aimed to investigate the therapeutic effects of Ginkgo biloba leaf extract (GBE) on AD and explore its potential mechanisms of action.

Methods: Key chemical components of GBE, including quercetin, luteolin, and kaempferol, were identified using network pharmacology methods. Bioinformatics analysis revealed their potential roles in AD through modulation of the PI3K/AKT/NF-κB signaling pathway.

Results: Mouse experiments demonstrated that GBE improved cognitive function, enhanced neuronal morphology, and reduced serum inflammatory factors. Additionally, GBE modulated the expression of relevant proteins and mRNA.

Conclusion: GBE shows promise as a potential treatment for AD. Its beneficial effects on cognitive function, neuronal morphology, and inflammation may be attributed to its modulation of the PI3K/AKT/NF-κB signaling pathway. These findings provide experimental evidence for the application of Ginkgo biloba leaf in AD treatment and highlight its potential mechanisms of action.

Citing Articles

Investigating the effects of Ginkgo biloba leaf extract on cognitive function in Alzheimer's disease.

Zhu C, Liu J, Lin J, Xu J, Yu E CNS Neurosci Ther. 2024; 30(9):e14914.

PMID: 39238068 PMC: 11377177. DOI: 10.1111/cns.14914.

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