Arrested Development: the Dysfunctional Life History of Medulloblastoma

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2024 Sep 4

PMID 39231614

Authors

Ran Tao

Katie Han

Stephanie C Wu

Jake D Friske

Martine F Roussel

Paul A Northcott

Affiliations

Soon will be listed here.

Abstract

Medulloblastoma is a heterogeneous embryonal tumor of the cerebellum comprised of four distinct molecular subgroups that differ in their developmental origins, genomic landscapes, clinical presentation, and survival. Recent characterization of the human fetal cerebellum at single-cell resolution has propelled unprecedented insights into the cellular origins of medulloblastoma subgroups, including those underlying previously elusive groups 3 and 4. In this review, the molecular pathogenesis of medulloblastoma is examined through the lens of cerebellar development. In addition, we discuss how enhanced understanding of medulloblastoma origins has the potential to refine disease modeling for the advancement of treatment and outcomes.

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