Metabolic Control of Microglia

Overview

Journal Adv Neurobiol

Publisher Springer

Date 2024 Aug 29

PMID 39207716

Authors

Monica Emili Garcia-Segura

Stefano Pluchino

Luca Peruzzotti-Jametti

Affiliations

Soon will be listed here.

Abstract

Microglia, immune sentinels of the central nervous system (CNS), play a critical role in maintaining its health and integrity. This chapter delves into the concept of immunometabolism, exploring how microglial metabolism shapes their diverse immune functions. It examines the impact of cell metabolism on microglia during various CNS states, including homeostasis, development, aging, and inflammation. Particularly in CNS inflammation, the chapter discusses how metabolic rewiring in microglia can initiate, resolve, or perpetuate inflammatory responses. The potential of targeting microglial metabolism as a therapeutic strategy for chronic CNS disorders with prominent innate immune cell activation is also explored.

References

Absinta M, Maric D, Gharagozloo M, Garton T, Smith M, Jin J . A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis. Nature. 2021; 597(7878):709-714. PMC: 8719282. DOI: 10.1038/s41586-021-03892-7. View

Albanese M, Zagaglia S, Landi D, Boffa L, Nicoletti C, Marciani M . Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression. J Neuroinflammation. 2016; 13:36. PMC: 4750170. DOI: 10.1186/s12974-016-0502-1. View

Bernier L, York E, Kamyabi A, Choi H, Weilinger N, MacVicar B . Microglial metabolic flexibility supports immune surveillance of the brain parenchyma. Nat Commun. 2020; 11(1):1559. PMC: 7096448. DOI: 10.1038/s41467-020-15267-z. View

Bernier L, York E, MacVicar B . Immunometabolism in the Brain: How Metabolism Shapes Microglial Function. Trends Neurosci. 2020; 43(11):854-869. DOI: 10.1016/j.tins.2020.08.008. View

Bisht K, Sharma K, Lecours C, Sanchez M, El Hajj H, Milior G . Dark microglia: A new phenotype predominantly associated with pathological states. Glia. 2016; 64(5):826-39. PMC: 4949554. DOI: 10.1002/glia.22966. View

Borst K, Schwabenland M, Prinz M . Microglia metabolism in health and disease. Neurochem Int. 2018; 130:104331. DOI: 10.1016/j.neuint.2018.11.006. View

Borst K, Dumas A, Prinz M . Microglia: Immune and non-immune functions. Immunity. 2021; 54(10):2194-2208. DOI: 10.1016/j.immuni.2021.09.014. View

Bruce K, Gorkhali S, Given K, Coates A, Boyle K, Macklin W . Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018; 11:57. PMC: 5862862. DOI: 10.3389/fnmol.2018.00057. View

Butler M, Cole R, Deems N, Belury M, Barrientos R . Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain Behav Immun. 2020; 89:145-158. PMC: 7572563. DOI: 10.1016/j.bbi.2020.06.010. View

10.

Cantuti-Castelvetri L, Fitzner D, Bosch-Queralt M, Weil M, Su M, Sen P . Defective cholesterol clearance limits remyelination in the aged central nervous system. Science. 2018; 359(6376):684-688. DOI: 10.1126/science.aan4183. View

11.

Cantuti-Castelvetri L, Gokce O, Simons M . Reparative inflammation in multiple sclerosis. Semin Immunol. 2022; 59:101630. DOI: 10.1016/j.smim.2022.101630. View

12.

Castoldi A, Monteiro L, van Teijlingen Bakker N, Sanin D, Rana N, Corrado M . Triacylglycerol synthesis enhances macrophage inflammatory function. Nat Commun. 2020; 11(1):4107. PMC: 7427976. DOI: 10.1038/s41467-020-17881-3. View

13.

Chen Y, Colonna M . Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?. J Exp Med. 2021; 218(9). PMC: 8302448. DOI: 10.1084/jem.20202717. View

14.

Chen S, Zhang H, Pu H, Wang G, Li W, Leak R . n-3 PUFA supplementation benefits microglial responses to myelin pathology. Sci Rep. 2014; 4:7458. PMC: 4264015. DOI: 10.1038/srep07458. View

15.

Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte M . Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. Circ Res. 2019; 125(12):1087-1102. PMC: 6921463. DOI: 10.1161/CIRCRESAHA.119.315833. View

16.

Cheng A, Jia W, Kawahata I, Fukunaga K . A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models. EBioMedicine. 2021; 72:103582. PMC: 8502714. DOI: 10.1016/j.ebiom.2021.103582. View

17.

Cherry J, Olschowka J, OBanion M . Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation. 2014; 11:98. PMC: 4060849. DOI: 10.1186/1742-2094-11-98. View

18.

Chiurchiu V, Leuti A, Maccarrone M . Bioactive Lipids and Chronic Inflammation: Managing the Fire Within. Front Immunol. 2018; 9:38. PMC: 5797284. DOI: 10.3389/fimmu.2018.00038. View

19.

Choi B, Kim J, Kho A, Kim I, Lee S, Lee B . Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice. J Neuroinflammation. 2015; 12:104. PMC: 4449958. DOI: 10.1186/s12974-015-0325-5. View

20.

De Smedt-Peyrusse V, Sargueil F, Moranis A, Harizi H, Mongrand S, Laye S . Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. J Neurochem. 2007; 105(2):296-307. DOI: 10.1111/j.1471-4159.2007.05129.x. View