Regulating Aggregation-Induced Emission Luminogen for Multimodal Imaging-Navigated Synergistic Therapy Involving Anti-Angiogenesis

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2024 Aug 29

PMID 39206553

Authors

Fei Zhang

Jie Cui

Yao Zhang

Miao Yan

Xiaoxiao Wu

Xue Liu

Dingyuan Yan

Zhijun Zhang

Ting Han

Hui Tan

Dong Wang

Ben Zhong Tang

Affiliations

Soon will be listed here.

Abstract

As a new avenue for cancer research, phototheranostics has shown inexhaustible and vigorous vitality as it permits real-time diagnosis and concurrent in situ therapy upon non-invasive light-initiation. However, construction of an advanced material, allowing prominent phototheranostic outputs and synchronously surmounting the inherent deficiency of phototheranostics, would be an appealing yet significantly challenging task. Herein, an aggregation-induced emission (AIE)-active luminogen (namely DBD-TM) featured by intensive electron donor-acceptor strength and twisted architecture with finely modulated intramolecular motion, is tactfully designed and prepared. DBD-TM simultaneously possessed fluorescence emission in the second near-infrared (NIR-II) region and high-efficiency photothermal conversion. By integrating DBD-TM with anti-angiogenic agent sorafenib, a versatile nanomaterial is smoothly fabricated and utilized for trimodal imaging-navigated synergistic therapy involving photothermal therapy and anti-angiogenesis toward cancer. This advanced approach is capable of affording accurate tumor diagnosis, complete tumor elimination, and largely restrained tumor recurrence, evidently denoting a prominent theranostic formula beyond phototheranostics. This study will offer a blueprint for exploiting a new generation of cancer theranostics.

Citing Articles

Regulating Aggregation-Induced Emission Luminogen for Multimodal Imaging-Navigated Synergistic Therapy Involving Anti-Angiogenesis.

Zhang F, Cui J, Zhang Y, Yan M, Wu X, Liu X Adv Sci (Weinh). 2024; 11(40):e2302713.

PMID: 39206553 PMC: 11515900. DOI: 10.1002/advs.202302713.

References

Liu Y, Bhattarai P, Dai Z, Chen X . Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2018; 48(7):2053-2108. PMC: 6437026. DOI: 10.1039/c8cs00618k. View

Calderwood S, Gong J . Heat Shock Proteins Promote Cancer: It's a Protection Racket. Trends Biochem Sci. 2016; 41(4):311-323. PMC: 4911230. DOI: 10.1016/j.tibs.2016.01.003. View

Li J, Pu K . Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation. Chem Soc Rev. 2018; 48(1):38-71. DOI: 10.1039/c8cs00001h. View

de Palma M, Biziato D, Petrova T . Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017; 17(8):457-474. DOI: 10.1038/nrc.2017.51. View

Torok S, Rezeli M, Kelemen O, Vegvari A, Watanabe K, Sugihara Y . Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors. Theranostics. 2017; 7(2):400-412. PMC: 5197073. DOI: 10.7150/thno.16767. View

Wang S, Tian Y, Tian W, Sun J, Zhao S, Liu Y . Selectively Sensitizing Malignant Cells to Photothermal Therapy Using a CD44-Targeting Heat Shock Protein 72 Depletion Nanosystem. ACS Nano. 2016; 10(9):8578-90. DOI: 10.1021/acsnano.6b03874. View

Cui J, Zhang F, Yan D, Han T, Wang L, Wang D . "Trojan Horse" Phototheranostics: Fine-Engineering NIR-II AIEgen Camouflaged by Cancer Cell Membrane for Homologous-Targeting Multimodal Imaging-Guided Phototherapy. Adv Mater. 2023; 35(33):e2302639. DOI: 10.1002/adma.202302639. View

Kim C, Yang H, Fukushima Y, Saw P, Lee J, Park J . Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. 2014; 25(1):102-17. DOI: 10.1016/j.ccr.2013.12.010. View

Tang Z, Zhang H, Liu Y, Ni D, Zhang H, Zhang J . Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy. Adv Mater. 2017; 29(47). DOI: 10.1002/adma.201701683. View

10.

Xiao P, Xie W, Zhang J, Wu Q, Shen Z, Guo C . De Novo Design of Reversibly pH-Switchable NIR-II Aggregation-Induced Emission Luminogens for Efficient Phototheranostics of Patient-Derived Tumor Xenografts. J Am Chem Soc. 2022; 145(1):334-344. DOI: 10.1021/jacs.2c10076. View

11.

Qin Y, Chen X, Gui Y, Wang H, Tang B, Wang D . Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics. J Am Chem Soc. 2022; 144(28):12825-12833. DOI: 10.1021/jacs.2c03895. View

12.

Zhang Y, Yang D, Chen H, Lim W, Phua F, An G . Reduction-sensitive fluorescence enhanced polymeric prodrug nanoparticles for combinational photothermal-chemotherapy. Biomaterials. 2018; 163:14-24. DOI: 10.1016/j.biomaterials.2018.02.023. View

13.

Lin H, Wang X, Yu L, Chen Y, Shi J . Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion. Nano Lett. 2016; 17(1):384-391. DOI: 10.1021/acs.nanolett.6b04339. View

14.

Yao X, Niu X, Ma K, Huang P, Grothe J, Kaskel S . Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy. Small. 2016; 13(2). DOI: 10.1002/smll.201602225. View

15.

Chu K, Dupuy D . Thermal ablation of tumours: biological mechanisms and advances in therapy. Nat Rev Cancer. 2014; 14(3):199-208. DOI: 10.1038/nrc3672. View

16.

Lyu Y, Fang Y, Miao Q, Zhen X, Ding D, Pu K . Intraparticle Molecular Orbital Engineering of Semiconducting Polymer Nanoparticles as Amplified Theranostics for in Vivo Photoacoustic Imaging and Photothermal Therapy. ACS Nano. 2016; 10(4):4472-81. DOI: 10.1021/acsnano.6b00168. View

17.

Nie L, Xing D, Yang S . In vivo detection and imaging of low-density foreign body with microwave-induced thermoacoustic tomography. Med Phys. 2009; 36(8):3429-37. DOI: 10.1118/1.3157204. View

18.

Deng X, Li K, Cai X, Liu B, Wei Y, Deng K . A Hollow-Structured CuS@Cu S@Au Nanohybrid: Synergistically Enhanced Photothermal Efficiency and Photoswitchable Targeting Effect for Cancer Theranostics. Adv Mater. 2017; 29(36). DOI: 10.1002/adma.201701266. View

19.

Tozer G, Kanthou C, Baguley B . Disrupting tumour blood vessels. Nat Rev Cancer. 2005; 5(6):423-35. DOI: 10.1038/nrc1628. View

20.

Zhang Y, Chen Y, Zhang D, Wang L, Lu T, Jiao Y . Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2017; 61(1):140-157. DOI: 10.1021/acs.jmedchem.7b01091. View