Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of L

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2024 Aug 29

PMID 39204101

Authors

Akmaral Kozhantayeva

Nurgul Tursynova

Ainagul Kolpek

Yelaman Aibuldinov

Arailym Tursynova

Togzhan Mashan

Zhazira Mukazhanova

Manshuk Ibrayeva

Aizhan Zeinuldina

Aisha Nurlybayeva

Zhanar Iskakova

Yerbolat Tashenov

Affiliations

Soon will be listed here.

Abstract

The study investigates the phytochemical profile, antioxidant capacity, and antimicrobial activities of ethanol (ChL-EtOH) and ethyl acetate (ChL-EtOAc) extracts from L. (ChL) harvested in Kazakhstan. The ChL-EtOH extract exhibited higher total phenolic (267.48 ± 3.44 mg GAE/g DE) and flavonoid content (24.18 ± 1.06 mg QE/g DE) compared to ChL-EtOAc. HPLC-UV-ESI/MS identified key phenolic acids and flavonoids, including gallic acid, chlorogenic acid, and quercetin 3-glucoside. FT-IR analysis confirmed the presence of characteristic functional groups. Antioxidant assays revealed strong DPPH scavenging and FRAP activities, with ChL-EtOH showing superior results (IC = 21.31 ± 0.65 μg/mL and 18.13 ± 0.15 μg/mL, respectively). Additionally, ChL-EtOH displayed notable antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as well as the fungal strain . These findings suggest that ethanol extraction is more efficient for isolating bioactive compounds from ChL, underscoring its potential for pharmaceutical and nutraceutical applications.

Citing Articles

Phytochemical Insights and Therapeutic Potential of and .

Kozhantayeva A, Iskakova Z, Ibrayeva M, Sapiyeva A, Arkharbekova M, Tashenov Y Molecules. 2025; 30(5).

PMID: 40076409 PMC: 11901623. DOI: 10.3390/molecules30051186.

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