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The Impact of Environmental Factors on the Development of Autoimmune Thyroiditis-Review

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Journal Biomedicines
Date 2024 Aug 29
PMID 39200253
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Abstract

Autoimmune thyroiditis (Hashimoto's thyroiditis) is the most common autoimmune disease. It most often manifests itself as hypothyroidism but may also present with euthyroidism or even hyperthyroidism. The etiopathogenesis of autoimmune thyroiditis is still unclear. However, in addition to genetic and epigenetic factors, many environmental factors are known to increase the risk of developing AIT. In this review, we aimed to collect and analyze data connected with environmental factors and autoimmune thyroiditis development. Our review indicates iodine intake, vitamin D deficiency, selenium deficiency, viral infections caused by Epstein-Barr Virus (EBV), Human parvovirus B19 (PVB19), Human herpesvirus 6A (HHV-6A) and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bacterial infection caused by Helicobacter pylori, microbiome disruption, medications such as interferon-alpha and tyrosine kinase inhibitors, as well as stress, climate, and smoking can influence the risk of the occurrence of autoimmune thyroiditis. Having knowledge of risk factors allows for making changes to one's diet and lifestyle that will reduce the risk of developing the disease and alleviate the course of autoimmune thyroiditis.

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References
1.
Wu G, Zou D, Cai H, Liu Y . Ultrasonography in the diagnosis of Hashimoto's thyroiditis. Front Biosci (Landmark Ed). 2016; 21(5):1006-12. DOI: 10.2741/4437. View

2.
Gombart A, Pierre A, Maggini S . A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020; 12(1). PMC: 7019735. DOI: 10.3390/nu12010236. View

3.
Udovcic M, Pena R, Patham B, Tabatabai L, Kansara A . Hypothyroidism and the Heart. Methodist Debakey Cardiovasc J. 2017; 13(2):55-59. PMC: 5512679. DOI: 10.14797/mdcj-13-2-55. View

4.
Heidari Z, Jami M . Parvovirus B19 Infection Is Associated with Autoimmune Thyroid Disease in Adults. Int J Endocrinol Metab. 2022; 19(4):e115592. PMC: 8762377. DOI: 10.5812/ijem.115592. View

5.
Faustino L, Lombardi A, Madrigal-Matute J, Owen R, Libutti S, Tomer Y . Interferon-α Triggers Autoimmune Thyroid Diseases via Lysosomal-Dependent Degradation of Thyroglobulin. J Clin Endocrinol Metab. 2018; 103(10):3678-3687. PMC: 6179164. DOI: 10.1210/jc.2018-00541. View