Supplementation Improves Glucose Tolerance in Intestinal Knockout Mice During the Daily Light to Dark Transition

Overview

Journal mSystems

Publisher American Society for Microbiology

Specialty Microbiology

Date 2023 Oct 3

PMID 37787527

Authors

Zhe Wang

Siyuan Cui

Tingting Zhang

Wei Wang

Jiayu Li

Y Q Chen

Sheng Long Zhu

Affiliations

Soon will be listed here.

Abstract

Alterations in the intestinal environment are associated with various diseases, and FFAR4 is abundantly enriched in the intestine, where it has been shown to have the ability to regulate intestinal hormone secretion and intestinal microbiota; here, we confirmed previous reports. Meanwhile, we found that intestinal FFAR4 regulates glucagon-like peptide 1 secretion by decreasing abundance and show that such change is associated with the level of glucose utilization at ZT12 in mice. Intestinal FFAR4 deficiency leads to severely impaired glucose tolerance at the ZT12 moment in mice, and supplementation ameliorates the abnormal glucose utilization at the ZT12 moment caused by FFAR4 deficiency, which is very similar to the dawn phenomenon in diabetic patients. Collectively, our data suggest that intestinal deteriorates glucose tolerance at the daily light to dark transition by affecting .

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