A Systematic Review and Meta-analysis on Prevalence of Bovine Trypanosomosis in East Africa

Overview

Journal Parasite Epidemiol Control

Specialty Parasitology

Date 2024 Aug 26

PMID 39184304

Authors

Getie Mulat

Moges Maru

Zewdu Seyoum Tarekegn

Haileyesus Dejene

Affiliations

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Abstract

Bovine trypanosomosis is an incapacitating and lethal ailment brought about by protozoan parasites of the genus Trypanosoma. The disease leads to losses in livestock and agricultural productivity, resulting in significant socio-economic repercussions. In East Africa, trypanosomosis has been endemic for an extensive period due to ecological factors and vector biology that facilitate the persistent circulation of trypanosomes. This investigation outlines the occurrence of bovine trypanosomosis in East Africa through a meta-analysis. A thorough search was conducted on PubMed, Google Scholar, Scopus, Web of Science and AJOL. Suitable studies were chosen using inclusion and exclusion criteria. The prevalence was estimated through a random effect model. Publication bias and the variation in prevalence estimates due to heterogeneity were also evaluated. The analysis was performed on 115 studies that contained relevant prevalence data. The collective estimate of bovine trypanosomosis prevalence across the studies stood at 12% (95% CI: 11, 13), ranging from 1% (95% CI: 0, 2) to 51% (95% CI: 45, 58). The subgroup analysis by country revealed considerable disparities in prevalence. The highest estimated prevalence was 24% (95% CI: 18, 30) in Somalia, whereas the lowest prevalence was observed in Ethiopia at 10% (95% CI: 9, 11). A significant level of heterogeneity was noted in most pooled estimates, even after conducting subgroup analysis. The visual examination of the funnel plot and the Egger's regression asymmetry coefficient (b = -5.13, 95% CI: -7.49, -2.76, = 0.00) and Begg's plot ( = 0.00) indicate the presence of publication bias. In conclusion, bovine trypanosomosis is a pervasive and noteworthy malady affecting livestock. The findings of this investigation imply a high prevalence of bovine trypanosomosis in the majority of the countries under scrutiny. Despite the well-known hindrance that livestock trypanosomosis poses to livestock production in Africa, little attention has been devoted to the trypanosomosis situation, particularly in East African nations.

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References

Angwech H, Nyeko J, Opiyo E, Okello-Onen J, Opiro R, Echodu R . Heterogeneity in the prevalence and intensity of bovine trypanosomiasis in the districts of Amuru and Nwoya, Northern Uganda. BMC Vet Res. 2015; 11:255. PMC: 4599665. DOI: 10.1186/s12917-015-0567-6. View

Duval S, Tweedie R . Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000; 56(2):455-63. DOI: 10.1111/j.0006-341x.2000.00455.x. View

Tsegaye G, Abebe B, Haile G . Prevalence of Bovine Trypanosomosis and Its Associated Risk Factor in Hawa Galan District, Kelem Wollega Zone of Ethiopia. Vet Med Int. 2021; 2021:4531586. PMC: 8692041. DOI: 10.1155/2021/4531586. View

Robi D, Diriba S . Epidemiological investigation of bovine trypanosomosis and distribution of vectors in Jimma zone, Ethiopia. Parasite Epidemiol Control. 2021; 14:e00221. PMC: 8367841. DOI: 10.1016/j.parepi.2021.e00221. View

Kizza D, Ocaido M, Mugisha A, Azuba R, Nalule S, Onyuth H . Prevalence and risk factors for trypanosome infection in cattle from communities surrounding the Murchison Falls National Park, Uganda. Parasit Vectors. 2021; 14(1):513. PMC: 8499574. DOI: 10.1186/s13071-021-04987-w. View

Ohaga S, Kokwaro E, Ndiege I, Hassanali A, Saini R . Livestock farmers' perception and epidemiology of bovine trypanosomosis in Kwale District, Kenya. Prev Vet Med. 2007; 80(1):24-33. DOI: 10.1016/j.prevetmed.2007.01.007. View

Sinshaw A, Abebe G, Desquesnes M, Yoni W . Biting flies and Trypanosoma vivax infection in three highland districts bordering lake Tana, Ethiopia. Vet Parasitol. 2006; 142(1-2):35-46. DOI: 10.1016/j.vetpar.2006.06.032. View

Sow A, Ganaba R, Percoma L, Sidibe I, Bengaly Z, Adam Y . Baseline survey of animal trypanosomosis in the region of the Boucle du Mouhoun, Burkina Faso. Res Vet Sci. 2013; 94(3):573-8. DOI: 10.1016/j.rvsc.2012.12.011. View

Leta S, Alemayehu G, Seyoum Z, Bezie M . Prevalence of bovine trypanosomosis in Ethiopia: a meta-analysis. Parasit Vectors. 2016; 9:139. PMC: 4785740. DOI: 10.1186/s13071-016-1404-x. View

10.

Aregawi W, Agga G, Abdi R, Buscher P . Systematic review and meta-analysis on the global distribution, host range, and prevalence of Trypanosoma evansi. Parasit Vectors. 2019; 12(1):67. PMC: 6357473. DOI: 10.1186/s13071-019-3311-4. View

11.

Tadesse A, Tsegaye B . Bovine trypanosomosis and its vectors in two districts of Bench Maji zone, South Western Ethiopia. Trop Anim Health Prod. 2010; 42(8):1757-62. DOI: 10.1007/s11250-010-9632-0. View

12.

Adam Y, Marcotty T, Cecchi G, Mahama C, Solano P, Bengaly Z . Bovine trypanosomosis in the Upper West Region of Ghana: entomological, parasitological and serological cross-sectional surveys. Res Vet Sci. 2011; 92(3):462-8. DOI: 10.1016/j.rvsc.2011.04.004. View

13.

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

14.

Sheferaw D, Birhanu B, Asrade B, Abera M, Tusse T, Fikadu A . Bovine trypanosomosis and Glossina distribution in selected areas of southern part of Rift Valley, Ethiopia. Acta Trop. 2015; 154:145-8. DOI: 10.1016/j.actatropica.2015.11.002. View

15.

Mekuria S, Ashenafi H, Kebede N, Kassa T, B Debella D, Eyasu T . Bovine trypanosomosis in upstream and downstream of Ghibe-III hydroelectric dam: parasitological and entomological study, southern Ethiopia. Vet Parasitol Reg Stud Reports. 2021; 23:100507. DOI: 10.1016/j.vprsr.2020.100507. View

16.

Hundessa N, Esrael E, Fesseha H, Mathewos M . Study on Prevalence of Trypanosomosis in Cattle of Sodo Zuriya District, Wolaita Zone, Southern Ethiopia. J Parasitol Res. 2021; 2021:4472480. PMC: 8683203. DOI: 10.1155/2021/4472480. View

17.

Moti Y, Fikru R, Buscher P, Van Den Abbeele J, Duchateau L, Delespaux V . Detection of African animal trypanosomes: the haematocrit centrifugation technique compared to PCR with samples stored on filter paper or in DNA protecting buffer. Vet Parasitol. 2014; 203(3-4):253-8. DOI: 10.1016/j.vetpar.2014.04.014. View

18.

Morrison L, Vezza L, Rowan T, Hope J . Animal African Trypanosomiasis: Time to Increase Focus on Clinically Relevant Parasite and Host Species. Trends Parasitol. 2016; 32(8):599-607. DOI: 10.1016/j.pt.2016.04.012. View

19.

Birhanu H, Fikru R, Said M, Kidane W, Gebrehiwot T, Hagos A . Epidemiology of Trypanosoma evansi and Trypanosoma vivax in domestic animals from selected districts of Tigray and Afar regions, Northern Ethiopia. Parasit Vectors. 2015; 8:212. PMC: 4403896. DOI: 10.1186/s13071-015-0818-1. View

20.

Ahmed S, Rahman A, Hassan M, Salih S, Paone M, Cecchi G . An atlas of tsetse and bovine trypanosomosis in Sudan. Parasit Vectors. 2016; 9:194. PMC: 4825090. DOI: 10.1186/s13071-016-1485-6. View