Systematic Review and Meta-analysis on the Global Distribution, Host Range, and Prevalence of Trypanosoma Evansi

Overview

Journal Parasit Vectors

Publisher Biomed Central

Specialties Parasitology
Tropical Medicine

Date 2019 Feb 2

PMID 30704516

Citations 69

Authors

Weldegebrial G Aregawi

Getahun E Agga

Reta D Abdi

Philippe Buscher

Affiliations

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Abstract

Background: Surra is an animal trypanosomosis, caused by infection with Trypanosoma evansi and leading to severe economic loss due to mortality and morbidity. Compared to tsetse-transmitted animal trypanosomoses, little attention is given to the epidemiology and control of surra. Understanding its epidemiology is a first step in local and global efforts to control the disease. We conducted a systematic review and meta-analysis of published studies on distribution, host ranges and prevalence of T. evansi infection.

Methods: Four electronic databases were searched for publications on T. evansi that met our inclusion criteria for the systematic review. Subsets of publications were subjected to meta-analysis for the pooled prevalence of T. evansi in various hosts as determined by multiple detection methods.

Results: A total of 272 references published between 1906-2017 were included. Trypanosoma evansi was reported from 48 countries; largely confined to Africa and Asia with publications on natural T. evansi infections from 77% (n = 48) of countries, contrasting with seven countries in South America, and four in Europe where T. evansi is not endemic but was imported with infected animals. Although surra is a notifiable disease, many countries do not report surra cases to OIE. Trypanosoma evansi was mainly reported from dromedary camels in Africa and the Middle East, water buffaloes, cattle, dogs and horses in East and Southeast Asia. In South America, the acute form of the disease was reported in horses and dogs. Surra was also reported in a wide range of wild animals. Some rare human cases occurred in India and Vietnam. Meta-analysis on a subset of 165 publications indicated pooled prevalence of T. evansi in domestic animals ranging from 14-31%, 6-28% and 2-9% using respectively antibody detection, molecular and parasitological tests, with camels as the most affected, followed by buffalo and cattle.

Conclusions: This study illustrates that T. evansi affects a wide range of domestic and wild animals in Africa, Asia and South America with highest prevalence observed in dromedary camels. For successful control of T. evansi, both locally and globally, the role of wild animals in the epidemiology of surra needs further investigation.

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References

Luckins A, Mehlitz D . Evaluation of an indirect fluorescent antibody test, enzyme-linked immunosorbent assay and quantification of immunoglobulins in the diagnosis of bovine trypanosomiasis. Trop Anim Health Prod. 1978; 10(3):149-59. DOI: 10.1007/BF02235328. View

HOARE C . Vampire bats as vectors and hosts of equine and bovine trypanosomes. Acta Trop. 1965; 22(3):204-16. View

Silveira J, Rabelo E, Lacerda A, Borges P, Tomas W, Pellegrin A . Molecular detection and identification of hemoparasites in pampas deer (Ozotoceros bezoarticus Linnaeus, 1758) from the Pantanal Brazil. Ticks Tick Borne Dis. 2013; 4(4):341-5. DOI: 10.1016/j.ttbdis.2013.01.008. View

Gutierrez C, Corbera J, Juste M, Doreste F, Morales I . An outbreak of abortions and high neonatal mortality associated with Trypanosoma evansi infection in dromedary camels in the Canary Islands. Vet Parasitol. 2005; 130(1-2):163-8. DOI: 10.1016/j.vetpar.2005.02.009. View

Adrian M, Sani R, Hassan L, Wong M . Outbreaks of trypanosomiasis and the seroprevalence of T. evansi in a deer breeding centre in Perak, Malaysia. Trop Anim Health Prod. 2009; 42(2):145-50. DOI: 10.1007/s11250-009-9406-8. View

Wilson A, Schwartz H, Dolan R, Olahu W . A simple classification of different types of trypanosomiasis occurring in four camel herds in selected areas of Kenya. Tropenmed Parasitol. 1983; 34(4):220-4. View

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

Sharma A, Singla L, Tuli A, Kaur P, Batth B, Javed M . Molecular prevalence of Babesia bigemina and Trypanosoma evansi in dairy animals from Punjab, India, by duplex PCR: a step forward to the detection and management of concurrent latent infections. Biomed Res Int. 2013; 2013:893862. PMC: 3773408. DOI: 10.1155/2013/893862. View

Olifiers N, Jansen A, Herrera H, Bianchi R, DAndrea P, de Miranda Mourao G . Co-Infection and Wild Animal Health: Effects of Trypanosomatids and Gastrointestinal Parasites on Coatis of the Brazilian Pantanal. PLoS One. 2015; 10(12):e0143997. PMC: 4678147. DOI: 10.1371/journal.pone.0143997. View

10.

Amer S, Ryu O, Tada C, Fukuda Y, Inoue N, Nakai Y . Molecular identification and phylogenetic analysis of Trypanosoma evansi from dromedary camels (Camelus dromedarius) in Egypt, a pilot study. Acta Trop. 2010; 117(1):39-46. DOI: 10.1016/j.actatropica.2010.09.010. View

11.

Herrera H, Abreu U, Keuroghlian A, Freitas T, Jansen A . The role played by sympatric collared peccary (Tayassu tajacu), white-lipped peccary (Tayassu pecari), and feral pig (Sus scrofa) as maintenance hosts for Trypanosoma evansi and Trypanosoma cruzi in a sylvatic area of Brazil. Parasitol Res. 2008; 103(3):619-24. DOI: 10.1007/s00436-008-1021-5. View

12.

Hussein K, Gasmir G . Presence of ketones in the serum of Trypanosoma evansi infected camels (Camelus dromedarius) in the Sudan. Rev Elev Med Vet Pays Trop. 1993; 46(4):578-9. View

13.

Herrera H, Rademaker V, Abreu U, DAndrea P, Jansen A . Variables that modulate the spatial distribution of Trypanosoma cruzi and Trypanosoma evansi in the Brazilian Pantanal. Acta Trop. 2007; 102(1):55-62. DOI: 10.1016/j.actatropica.2007.03.001. View

14.

Wuyts N, Chokesajjawatee N, Sarataphan N, Panyim S . PCR amplification of crude blood on microscope slides in the diagnosis of Trypanosoma evansi infection in dairy cattle. Ann Soc Belg Med Trop. 1995; 75(3):229-37. View

15.

Alves F, Olifiers N, Bianchi R, Duarte A, Cotias P, DAndrea P . Modulating variables of Trypanosoma cruzi and Trypanosoma evansi transmission in free-ranging Coati (Nasua nasua) from the Brazilian Pantanal region. Vector Borne Zoonotic Dis. 2010; 11(7):835-41. DOI: 10.1089/vbz.2010.0096. View

16.

Sangwan N, Chaudhri S, Rao A, Sangwan A, Gupta R . Folacin and cyanocobalamin in relation to natural Trypanosoma evansi infection in buffaloes. Trop Anim Health Prod. 1993; 25(2):79-84. DOI: 10.1007/BF02236509. View

17.

Mossaad E, Salim B, Suganuma K, Musinguzi P, Hassan M, Elamin E . Trypanosoma vivax is the second leading cause of camel trypanosomosis in Sudan after Trypanosoma evansi. Parasit Vectors. 2017; 10(1):176. PMC: 5390396. DOI: 10.1186/s13071-017-2117-5. View

18.

Milocco C, Kamyingkird K, Desquesnes M, Jittapalapong S, Herbreteau V, Chaval Y . Molecular demonstration of Trypanosoma evansi and Trypanosoma lewisi DNA in wild rodents from Cambodia, Lao PDR and Thailand. Transbound Emerg Dis. 2012; 60(1):17-26. DOI: 10.1111/j.1865-1682.2012.01314.x. View

19.

Bono Battistoni M, Orcellet V, Peralta J, Marengo R, Plaza D, Brunini A . First report of Trypanosoma evansi in a canine in Argentina. Vet Parasitol Reg Stud Reports. 2019; 6:1-3. DOI: 10.1016/j.vprsr.2016.10.001. View

20.

Payne R, Sukanto I, Bazeley K, Jones T . The effect of Trypanosoma evansi infection on the oestrous cycle of Friesian Holstein heifers. Vet Parasitol. 1993; 51(1-2):1-11. DOI: 10.1016/0304-4017(93)90190-x. View