The Molecular Conversations of Sarcomas: Exosomal Non-coding RNAs in Tumor's Biology and Their Translational Prospects

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2024 Aug 22

PMID 39174949

Authors

Margherita Luongo

Pasqualina Laurenziello

Giuseppe Cesta

Anna Maria Bochicchio

Ludmila Carmen Omer

Geppino Falco

Maria Rita Milone

Francesca Cibarelli

Sabino Russi

Simona Laurino

Affiliations

Soon will be listed here.

Abstract

Exosomes mediate cell-to-cell crosstalk involving a variety of biomolecules through an intricate signaling network. In recent years, the pivotal role of exosomes and their non-coding RNAs cargo in the development and progression of several cancer types clearly emerged. In particular, tumor bulk and its microenvironment co-evolve through cellular communications where these nanosized extracellular vesicles are among the most relevant actors. Knowledge about the cellular, and molecular mechanisms involved in these communications will pave the way for novel exosome-based delivery of therapeutic RNAs as well as innovative prognostic/diagnostic tools. Despite the valuable therapeutic potential and clinical relevance of exosomes, their role on sarcoma has been vaguely reported because the rarity and high heterogeneity of this type of cancer. Here, we dissected the scientific literature to unravel the multifaceted role of exosomal non-coding RNAs as mediator of cell-to-cell communications in the sarcoma subtypes.

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References

Peterson J, Kransdorf M, Bancroft L, OConnor M . Malignant fatty tumors: classification, clinical course, imaging appearance and treatment. Skeletal Radiol. 2003; 32(9):493-503. DOI: 10.1007/s00256-003-0647-8. View

Lagerweij T, Perez-Lanzon M, Baglio S . A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells. J Vis Exp. 2018; (135). PMC: 6101124. DOI: 10.3791/56932. View

Dores M, Grimsey N, Mendez F, Trejo J . ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif. PLoS One. 2016; 11(6):e0157587. PMC: 4907476. DOI: 10.1371/journal.pone.0157587. View

Wu K, Lin K, Li X, Yuan X, Xu P, Ni P . Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment. Front Immunol. 2020; 11:1731. PMC: 7417513. DOI: 10.3389/fimmu.2020.01731. View

Yang H, He C, Feng Y, Jin J . Exosome‑delivered miR‑486‑3p inhibits the progression of osteosarcoma via sponging CircKEAP1/MARCH1 axis components. Oncol Lett. 2023; 27(1):24. PMC: 10696630. DOI: 10.3892/ol.2023.14157. View

Qin F, Tang H, Zhang Y, Zhang Z, Huang P, Zhu J . Bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-208a promotes osteosarcoma cell proliferation, migration, and invasion. J Cell Physiol. 2019; 235(5):4734-4745. DOI: 10.1002/jcp.29351. View

Lee A, Thway K, Huang P, Jones R . Clinical and Molecular Spectrum of Liposarcoma. J Clin Oncol. 2017; 36(2):151-159. PMC: 5759315. DOI: 10.1200/JCO.2017.74.9598. View

Meng C, Yang Y, Feng W, Ma P, Bai R . Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy. J Orthop Surg Res. 2023; 18(1):892. PMC: 10666460. DOI: 10.1186/s13018-023-04338-8. View

Ashwal-Fluss R, Meyer M, Pamudurti N, Ivanov A, Bartok O, Hanan M . circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014; 56(1):55-66. DOI: 10.1016/j.molcel.2014.08.019. View

10.

Ghamloush F, Ghayad S, Rammal G, Fahs A, Ayoub A, Merabi Z . The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486. Sci Rep. 2019; 9(1):14242. PMC: 6775163. DOI: 10.1038/s41598-019-50592-4. View

11.

Thway K, Fisher C . Synovial sarcoma: defining features and diagnostic evolution. Ann Diagn Pathol. 2014; 18(6):369-80. DOI: 10.1016/j.anndiagpath.2014.09.002. View

12.

Rammal G, Fahs A, Kobeissy F, Mechref Y, Zhao J, Zhu R . Proteomic Profiling of Rhabdomyosarcoma-Derived Exosomes Yield Insights into Their Functional Role in Paracrine Signaling. J Proteome Res. 2019; 18(10):3567-3579. DOI: 10.1021/acs.jproteome.9b00157. View

13.

Tewfik J, Greene G . Fluorine-18-deoxyglucose-positron emission tomography imaging with magnetic resonance and computed tomographic correlation in the evaluation of bone and soft-tissue sarcomas: a pictorial essay. Curr Probl Diagn Radiol. 2008; 37(4):178-88. DOI: 10.1067/j.cpradiol.2007.10.005. View

14.

Gassmann H, Schneider K, Evdokimova V, Ruzanov P, Schober S, Xue B . Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function. Cells. 2021; 10(8). PMC: 8391167. DOI: 10.3390/cells10082081. View

15.

Laurino S, Omer L, Albano F, Marino G, Bianculli A, Solazzo A . Radiation-induced sarcomas: A single referral cancer center experience and literature review. Front Oncol. 2022; 12:986123. PMC: 9561616. DOI: 10.3389/fonc.2022.986123. View

16.

Galardi A, Colletti M, Di Paolo V, Vitullo P, Antonetti L, Russo I . Exosomal MiRNAs in Pediatric Cancers. Int J Mol Sci. 2019; 20(18). PMC: 6770697. DOI: 10.3390/ijms20184600. View

17.

Zhang H, Wang J, Ren T, Huang Y, Liang X, Yu Y . Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B. Cancer Lett. 2020; 490:54-65. DOI: 10.1016/j.canlet.2020.07.008. View

18.

Hosseinikhah S, Gheybi F, Moosavian S, Shahbazi M, Jaafari M, Sillanpaa M . Role of exosomes in tumour growth, chemoresistance and immunity: state-of-the-art. J Drug Target. 2022; 31(1):32-50. DOI: 10.1080/1061186X.2022.2114000. View

19.

Muskan M, Abeysinghe P, Cecchin R, Branscome H, Morris K, Kashanchi F . Therapeutic potential of RNA-enriched extracellular vesicles: The next generation in RNA delivery via biogenic nanoparticles. Mol Ther. 2024; 32(9):2939-2949. PMC: 11403218. DOI: 10.1016/j.ymthe.2024.02.025. View

20.

Li Y, Lin S, Xie X, Zhu H, Fan T, Wang S . Highly enriched exosomal lncRNA OIP5-AS1 regulates osteosarcoma tumor angiogenesis and autophagy through miR-153 and ATG5. Am J Transl Res. 2021; 13(5):4211-4223. PMC: 8205742. View