Progression of Spontaneous Malignant Transformation of Epithelial Rat Liver Cell Lines

Overview

Journal Cell Biol Toxicol

Publisher Springer

Specialties Cell Biology
Toxicology

Date 1985 Jan 1

PMID 3917123

Citations 1

Authors

C Lafarge-Frayssinet

G Trincal

Affiliations

Soon will be listed here.

Abstract

Cultured epithelial cell lines from normal rat livers were shown to undergo gradual transformation and malignancy which increased with time. Morphological changes appeared both before and after cells had attained a malignant state, as detected by agar tests. The progression of the degree of malignancy was determined by the morphological appearance of the cells, the increase in the number and size of cell colonies in soft agar, the expression of gamma glutamyl transferase (gamma GT) and the shortening of the latency period necessary for tumor formation after transplantation to syngeneic rats of cells from sequential passages.

Citing Articles

Use of cell cultures for predicting the biological effects of mycotoxins.

Lafarge-Frayssinet C, Frayssinet C Cell Biol Toxicol. 1989; 5(2):217-26.

PMID: 2766030 DOI: 10.1007/BF00122655.

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