Management of Bilateral Head and Neck Paragangliomas at a Single-institution Across Four Decades

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2024 Aug 22

PMID 39169604

Authors

Nikhil Bellamkonda

Evan L Tooker

Anne Naumer

Luke O Buchmann

Wendy Kohlmann

Hilary C McCrary

Neil S Patel

Mana Espahbodi

Affiliations

Soon will be listed here.

Abstract

Background: Bilateral head and neck paragangliomas (HNPGLs) require nuanced management to balance tumor control with functional preservation.

Methods: All patients seen at a single-institution for bilateral paraganglioma between 1983 and 2023 were retrospectively reviewed. Demographics, genetic testing results, and tumor characteristics were analyzed and compared to treatment modality and cranial nerve outcomes.

Results: There were 49 patients with 116 tumors (90 carotid body tumors [CBTs], 15 vagal paragangliomas [VPs], and 11 jugular paragangliomas [JPs]). Twenty-six patients had SDH pathologic variants (PV). Surgical management was more commonly utilized in younger patients (OR: 0.97, 95% CI: 0.950-0.992) and for JPs (OR: 9, 95% CI: 1.386-58.443). In surgical cases, CBTs had a lower risk of postoperative cranial nerve deficits compared to JPs and VPs (OR: 0.095, 95% CI: 0.013-0.692).

Conclusions: Younger patients with bilateral HNPGLs, especially those with JP and CBT, are more often treated with surgery. CBTs have lowest risk of cranial nerve deficits after surgery.

Citing Articles

Management of bilateral head and neck paragangliomas at a single-institution across four decades.

Bellamkonda N, Tooker E, Naumer A, Buchmann L, Kohlmann W, McCrary H Head Neck. 2024; 47(1):386-393.

PMID: 39169604 PMC: 11635744. DOI: 10.1002/hed.27923.

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