Association of Periodontitis with Cardiovascular and All-cause Mortality in Hypertensive Individuals: Insights from a NHANES Cohort Study

Overview

Journal BMC Oral Health

Publisher Biomed Central

Specialty Dentistry

Date 2024 Aug 16

PMID 39152381

Authors

Jingru Li

Yajun Yao

Wenchao Yin

Shuai Feng

Pengcheng Yan

Leiyan Wang

Xiao Zhu

Kaiwen Zhang

Jingjing Tian

Zhaoyang Wang

Haitao Yuan

Affiliations

Soon will be listed here.

Abstract

Background: The objective of this research is to clarify the impact of periodontitis on overall and cardiovascular-related death rates among hypertensive individuals.

Method: A total of 5665 individuals with hypertension were included from the National Health and Nutrition Examination Survey (NHANES) data spanning 2001-2004 and 2009-2014. These individuals were divided into two groups based on the presence or absence of periodontitis and further stratified by the severity of periodontitis. We employed weighted multivariate Cox proportional hazards regression and Kaplan-Meier curves (log-rank test) to evaluate the impact of periodontitis on all-cause and cardiovascular mortality. Additional analyses, including adjustments for various covariates, subgroups, and sensitivity analyses, were conducted to ensure the robustness and reliability of our results.

Result: Over an average follow-up duration of 10.22 years, there were 1,122 all-cause and 297 cardiovascular deaths. Individuals with periodontitis exhibited an elevated risk of all-cause mortality (HR = 1.33, 95% CI 1.18-1.51; p < 0.0001) and cardiovascular mortality (HR = 1.48, 95% CI 1.15-1.89; p = 0.002). Moreover, we observed a progressive increase in both all-cause mortality and cardiovascular mortality (p for trend are both lower than 0.001) and correlating with the severity of periodontitis. These associations remained consistent across various subgroup and sensitivity analyses.

Conclusion: Our findings suggest a significant association between periodontitis and increased risks of all-cause and cardiovascular mortality among hypertensive individuals. Notably, the severity of periodontitis appears to be a critical factor, with moderate to severe cases exerting a more pronounced impact on all-cause mortality. Additionally, cardiovascular disease mortality significantlly increases in individuals with varying degrees of periodontitis.

Citing Articles

The Association Between Periodontitis and the Prevalence and Prognosis of Metabolic Syndrome.

Li T, Wu H, Fu Z, Li H, Li Q, Liu Y J Multidiscip Healthc. 2025; 18:1053-1065.

PMID: 40008287 PMC: 11853064. DOI: 10.2147/JMDH.S499516.

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