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Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisited

Overview

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2021 Feb 1

PMID 33521070

Citations 65

Authors

Authors

Faraedon Zardawi

Sarhang Gul

Ali Abdulkareem

Aram Sha

Julian Yates

Affiliations

Affiliations

Soon will be listed here.

Abstract

Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary arteries associated with atheroma formation, which can cause disability and often death. Periodontitis is ranked as the sixth most prevalent disease affecting humans affecting 740 million people worldwide. In the last few decades, researchers have focused on the effect of periodontal disease (PD) on cardiovascular disease. The aim of this review was to investigate the association between these two diseases. PD is a potential risk factor that may initiate the development, maturation, and instability of atheroma in the arteries. Two mechanisms were proposed to explain such association, either periodontal pathogens directly invade bloodstream or indirectly by increasing systemic level of inflammatory mediators. Interestingly, it has been suggested that improvement in the condition of one disease positively impact the condition of the other one. Highlighting the association between these two diseases, the importance of early diagnosis and treatment of PD and its impact on cardiovascular status may be of great value in reducing the complications associated with ACVDs. Further and studies with longer follow up are necessary to confirm the causal relationship between PD and ACVDs.

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