Absorption of Bioactive Peptides Following Collagen Hydrolysate Intake: a Randomized, Double-blind Crossover Study in Healthy Individuals

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2024 Aug 16

PMID 39149544

Authors

Nicolina Virgilio

Christiane Schon

Yvonne Modinger

Bastiaan van der Steen

Sara Vleminckx

Frederique L van Holthoon

Anne J Kleinnijenhuis

Catarina I F Silva

Janne Prawitt

Affiliations

Soon will be listed here.

Abstract

Background: Collagen hydrolysates (CH) in functional foods and supplements are dietary sources of amino acids (AAs) and di-and tripeptides linked to various health benefits. This study aimed to investigate the single-dose bioavailability of skin- and hide-derived CH from fish, porcine and bovine origin with different molecular weights (bovine 2,000 and 5,000 Da).

Methods: A randomized, double-blind crossover clinical study was performed with healthy volunteers assessing the plasma concentration of free and peptide-bound hydroxyproline (Hyp) as well as selected peptides reported to be abundantly present in collagen.

Results: The pharmacokinetic endpoints demonstrated comparable uptake of free Hyp from all CH. A higher amount of total compared to free Hyp indicated the uptake of substantial amounts of Hyp-containing di- or tripeptides.

Conclusion: Independently of source and molecular weight, all CH yielded relevant plasma concentrations of the investigated metabolites. Larger studies are needed to estimate an ideal level of selected circulating metabolites needed to trigger distinct physiological reactions in target tissues.

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