Bacteriocin Production Facilitates Nosocomial Emergence of Vancomycin-resistant

Overview

Journal medRxiv

Date 2024 Aug 12

PMID 39132485

Authors

Emma G Mills

Alexander B Smith

Marissa P Griffith

Katharine Hewlett

Lora Pless

Alexander J Sundermann

Lee H Harrison

Joseph P Zackular

Daria Van Tyne

Affiliations

Soon will be listed here.

Abstract

Vancomycin-resistant (VREfm) is a prevalent healthcare-acquired pathogen. Gastrointestinal colonization can lead to difficult-to-treat bloodstream infections with high mortality rates. Prior studies have investigated VREfm population structure within healthcare centers. However, little is known about how and why hospital-adapted VREfm populations change over time. We sequenced 710 healthcare-associated VREfm clinical isolates from 2017-2022 from a large tertiary care center as part of the Enhanced Detection System for Healthcare-Associated Transmission (EDS-HAT) program. Although the VREfm population in our center was polyclonal, 46% of isolates formed genetically related clusters, suggesting a high transmission rate. We compared our collection to 15,631 publicly available VREfm genomes spanning 20 years. Our findings describe a drastic shift in lineage replacement within nosocomial VREfm populations at both the local and global level. Functional and genomic analysis revealed, antimicrobial peptide, bacteriocin T8 may be a driving feature of strain emergence and persistence in the hospital setting.

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