Boundarics in Biomedicine

Overview

Journal Research (Wash D C)

Specialty Biology

Date 2024 Aug 12

PMID 39130494

Authors

Quansheng Du

Juan Li

Fang Yang

Hui Dai

Aiguo Wu

Affiliations

Soon will be listed here.

Abstract

"Boundarics in Biomedicine" is a cutting-edge interdisciplinary discipline, which is of great significance for understanding the origin of life, the interaction between internal and external environments, and the mechanism of disease occurrence and evolution. Here, the definition of Boundarics in Biomedicine is first described, including its connotation, research object, research method, challenges, and future perspectives. "Boundarics in Biomedicine" is a cutting-edge interdisciplinary discipline involving multiple fields (e.g., bioscience, medicine, chemistry, materials science, and information science) dedicated to investigating and solving key scientific questions in the formation, identification, and evolution of living organism boundaries. Specifically, it encompasses 3 levels: (a) the boundary between the living organism and the external environment, (b) internal boundary within living organism, and (c) the boundary related to disease in living organism. The advancement of research in Boundarics in Biomedicine is of great scientific significance for understanding the origin of life, the interaction between internal and external environments, and the mechanism of disease occurrence and evolution, thus providing novel principles, technologies, and methods for early diagnosis and prevention of major diseases, personalized drug development, and prognosis assessment (Fig. 1).

References

Todo T, Ito H, Ino Y, Ohtsu H, Ota Y, Shibahara J . Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial. Nat Med. 2022; 28(8):1630-1639. PMC: 9388376. DOI: 10.1038/s41591-022-01897-x. View

Lenne P, Trivedi V . Sculpting tissues by phase transitions. Nat Commun. 2022; 13(1):664. PMC: 8814027. DOI: 10.1038/s41467-022-28151-9. View

Sun L, Fan L, Bian F, Chen G, Wang Y, Zhao Y . MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing. Research (Wash D C). 2021; 2021:9838490. PMC: 8267825. DOI: 10.34133/2021/9838490. View

Duan X, Wang P, He L, He Z, Wang S, Yang F . Peptide-Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy. Adv Mater. 2024; 36(37):e2311548. DOI: 10.1002/adma.202311548. View

Shen Z, Song J, Zhou Z, Yung B, Aronova M, Li Y . Dotted Core-Shell Nanoparticles for T -Weighted MRI of Tumors. Adv Mater. 2018; :e1803163. PMC: 6320323. DOI: 10.1002/adma.201803163. View

Li Z, Zheng Q, Wang Z, Li Z . Nanogenerator-Based Self-Powered Sensors for Wearable and Implantable Electronics. Research (Wash D C). 2020; 2020:8710686. PMC: 7085499. DOI: 10.34133/2020/8710686. View

Castellani G, Croese T, Peralta Ramos J, Schwartz M . Transforming the understanding of brain immunity. Science. 2023; 380(6640):eabo7649. DOI: 10.1126/science.abo7649. View

Pal R, Lwin T, Krishnamoorthy M, Collins H, Chan C, Prilutskiy A . Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients. Nat Biomed Eng. 2023; 7(12):1649-1666. DOI: 10.1038/s41551-023-01105-2. View

Yan J, Bai Y, Chen F, Zou X, Xu J, Huang A . An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression. Cell Res. 2023; 33(8):585-603. PMC: 10397313. DOI: 10.1038/s41422-023-00831-1. View

10.

Wang L, Gao H, Sun H, Ji Y, Song L, Jia L . Reconfigurable Vortex-like Paramagnetic Nanoparticle Swarm with Upstream Motility and High Body-length Ratio Velocity. Research (Wash D C). 2023; 6:0088. PMC: 10042322. DOI: 10.34133/research.0088. View

11.

Chen G, Yu Y, Wu X, Wang G, Gu G, Wang F . Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing. Research (Wash D C). 2019; 2019:6175398. PMC: 6750103. DOI: 10.34133/2019/6175398. View

12.

Zhu M, Zhang K, Tao H, Hopyan S, Sun Y . Magnetic Micromanipulation for Measurement of Stiffness Heterogeneity and Anisotropy in the Mouse Mandibular Arch. Research (Wash D C). 2020; 2020:7914074. PMC: 7327709. DOI: 10.34133/2020/7914074. View

13.

Du H, Yang F, Yao C, Zhong Z, Jiang P, Stanciu S . Multifunctional Modulation of High-Performance Zn Fe O Nanoparticles by Precisely Tuning the Zinc Doping Content. Small. 2022; 18(42):e2201669. DOI: 10.1002/smll.202201669. View

14.

Yang Y, Chen Y, Pei P, Fan Y, Wang S, Zhang H . Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging. Nat Nanotechnol. 2023; 18(10):1195-1204. DOI: 10.1038/s41565-023-01422-2. View

15.

Wu L, Wu W, Zhang J, Zhao Z, Li L, Zhu M . Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma. Cancer Discov. 2022; 12(12):2820-2837. PMC: 9716251. DOI: 10.1158/2159-8290.CD-22-0196. View

16.

Wang Y, Zhou S, Wang Y, Lu Z, Zhang Y, Xu C . Engineering tumor-specific gene nanomedicine to recruit and activate T cells for enhanced immunotherapy. Nat Commun. 2023; 14(1):1993. PMC: 10082825. DOI: 10.1038/s41467-023-37656-w. View

17.

Mazzone P, Lam L . Evaluating the Patient With a Pulmonary Nodule: A Review. JAMA. 2022; 327(3):264-273. DOI: 10.1001/jama.2021.24287. View

18.

Liu R, Ye X, Cui T . Recent Progress of Biomarker Detection Sensors. Research (Wash D C). 2020; 2020:7949037. PMC: 7585038. DOI: 10.34133/2020/7949037. View

19.

Hu Z, Fang C, Li B, Zhang Z, Cao C, Cai M . First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows. Nat Biomed Eng. 2019; 4(3):259-271. DOI: 10.1038/s41551-019-0494-0. View

20.

Cao Y, Ge X, Zhu X, Han Y, Wang P, Akakuru O . Transformable Neuropeptide Prodrug with Tumor Microenvironment Responsiveness for Tumor Growth and Metastasis Inhibition of Triple-Negative Breast Cancer. Adv Sci (Weinh). 2023; 10(21):e2300545. PMC: 10375191. DOI: 10.1002/advs.202300545. View