Immunology of Cytokine Storm Syndromes: Natural Killer Cells

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2024 Aug 8

PMID 39117813

Authors

Anthony R French

Randy Q Cron

Megan A Cooper

Affiliations

Soon will be listed here.

Abstract

Natural killer (NK) cells are innate immune lymphocytes that rapidly produce cytokines upon activation and kill target cells. NK cells have been of particular interest in primary hemophagocytic lymphohistiocytosis (pHLH) since all of the genetic defects associated with this disorder cause diminished cytotoxic capacity of NK cells and T lymphocytes, and assays of NK cell killing are used clinically for the diagnosis of HLH. Herein, we review human NK cell biology and the significance of alterations in NK cell function in the diagnosis and pathogenesis of HLH.

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