What Goes Up Must Come Down: off Switches for Regulatory RNAs

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2024 Aug 7

PMID 39111824

Authors

Katherine McJunkin

Susan Gottesman

Affiliations

Soon will be listed here.

Abstract

Small RNAs base pair with and regulate mRNA translation and stability. For both bacterial small regulatory RNAs and eukaryotic microRNAs, association with partner proteins is critical for the stability and function of the regulatory RNAs. We review the mechanisms for degradation of these RNAs: displacement of the regulatory RNA from its protein partner (in bacteria) or destruction of the protein and its associated microRNAs (in eukaryotes). These mechanisms can allow specific destruction of a regulatory RNA via pairing with a decay trigger RNA or function as global off switches by disrupting the stability or function of the protein partner.

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