Acupuncture Improves the Live Birth of Patients with Repeated Implantation Failure: a Retrospective Cohort Study

Overview

Journal J Tradit Chin Med

Date 2024 Jul 27

PMID 39066544

Authors

Sun Junjian

Xie Henghui

L I Huanhuan

Tian Xiangming

Fang Yigong

Zhou Wenhui

Affiliations

Soon will be listed here.

Abstract

Objective: To explore the therapeutic efficacy of acupuncture treatment on repeated implantation failure (RIF) patients with cryo-thawed embryo transfer (CET).

Methods: In a retrospective cohort study, all eligible women undergoing RIF were recruited in our center from January 1, 2018 to December 31, 2021. The patients were grouped by whether an acceptance of acupuncture treatment before CET, including the acupuncture group (Acu-group, 55 cycles) and control group (Con-group, 244 cycles). Data were analyzed by using binary logistic regression to explore the relationship of acupuncture treatment with pregnancy outcomes.

Results: The Acu-group had higher live-birth rate (LBR) [54.5% 41.0%, respectively; odds ratio () = 1.105, 95% confidence interval () (1.029, 1.187), 0.006] and ongoing pregnancy rate (OPR) [56.4% 43.0%, respectively; = 1.100, 95% (1.025, 1.181), 0.008] than the Con-group. There were no significant between-group differences in the rates of implantation [= 1.070, 95% (0.996, 1.149), 0.064], clinical pregnancy [= 1.065, 95% (0.997, 1.138), 0.061], biochemical pregnancy [= 1.002, 95% (0.903, 1.112), 0.967], or miscarriage [= 0.778, 95% (0.551, 1.099), 0.155]. Perinatal outcomes did not differ significantly between the two groups.

Conclusions: Acupuncture treatment could improve the LBR and OPR in RIF patients with CET cycles, suggesting a potential adjuvant therapy of acupuncture to improve the pregnancy outcomes in RIF patients.

References

Pirtea P, de Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi J . Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertil Steril. 2020; 115(1):45-53. DOI: 10.1016/j.fertnstert.2020.07.002. View

Zhou W, Chu D, Sha W, Fu L, Li Y . Effects of granulocyte-macrophage colony-stimulating factor supplementation in culture medium on embryo quality and pregnancy outcome of women aged over 35 years. J Assist Reprod Genet. 2015; 33(1):39-47. PMC: 4717131. DOI: 10.1007/s10815-015-0627-7. View

Prapas Y, Prapas N, Jones E, Duleba A, Olive D, Chatziparasidou A . The window for embryo transfer in oocyte donation cycles depends on the duration of progesterone therapy. Hum Reprod. 1998; 13(3):720-3. DOI: 10.1093/humrep/13.3.720. View

Santillan I, Lozano I, Illan J, Verdu V, Coca S, Bajo-Arenas J . Where and when should natural killer cells be tested in women with repeated implantation failure?. J Reprod Immunol. 2015; 108:142-8. DOI: 10.1016/j.jri.2014.12.009. View

Huang D, Huang G, Lu F, Stefan D, Andreas N, Robert G . Acupuncture for infertility: is it an effective therapy?. Chin J Integr Med. 2011; 17(5):386-95. DOI: 10.1007/s11655-011-0611-8. View

Silberstein M . Do acupuncture meridians exist? Correlation with referred itch (mitempfindung) stimulus and referral points. Acupunct Med. 2012; 30(1):17-20. DOI: 10.1136/acupmed-2011-010091. View

Qu D, Tian X, Ding L, Li Y, Zhou W . Impacts of Cyclosporin A on clinical pregnancy outcomes of patients with a history of unexplained transfer failure: a retrospective cohort study. Reprod Biol Endocrinol. 2021; 19(1):44. PMC: 7962312. DOI: 10.1186/s12958-021-00728-x. View

Zhou W, Fu L, Sha W, Chu D, Li Y . Relationship of polar bodies morphology to embryo quality and pregnancy outcome. Zygote. 2015; 24(3):401-7. DOI: 10.1017/S0967199415000325. View

Zhao Z . Neural mechanism underlying acupuncture analgesia. Prog Neurobiol. 2008; 85(4):355-75. DOI: 10.1016/j.pneurobio.2008.05.004. View

10.

Tanos V, Friedler S, Zajicek G, Neiger M, Lewin A, Schenker J . The impact of endometrial preparation on implantation following cryopreserved-thawed-embryo transfer. Gynecol Obstet Invest. 1996; 41(4):227-31. DOI: 10.1159/000292274. View

11.

Paulus W, Zhang M, Strehler E, El-Danasouri I, Sterzik K . Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy. Fertil Steril. 2002; 77(4):721-4. DOI: 10.1016/s0015-0282(01)03273-3. View

12.

Szamatowicz M . [The role and place of the assisted reproductive technology (ART) in treatment of infertility]. Ginekol Pol. 2007; 78(3):175-9. View

13.

Ghobara T, Gelbaya T, Ayeleke R . Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev. 2017; 7:CD003414. PMC: 6483463. DOI: 10.1002/14651858.CD003414.pub3. View

14.

Liu X, Ma D, Wang W, Qu Q, Zhang N, Wang X . Intrauterine administration of human chorionic gonadotropin improves the live birth rates of patients with repeated implantation failure in frozen-thawed blastocyst transfer cycles by increasing the percentage of peripheral regulatory T cells. Arch Gynecol Obstet. 2019; 299(4):1165-1172. DOI: 10.1007/s00404-019-05047-6. View

15.

Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R . Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021; 385(22):2047-2058. DOI: 10.1056/NEJMoa2103613. View

16.

Gardner D, Schoolcraft W . Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol. 1999; 11(3):307-11. DOI: 10.1097/00001703-199906000-00013. View

17.

Eleftheriadou A, Francis A, Wilcox M, Jayaprakasan K . Frozen Blastocyst Embryo Transfer: Comparison of Protocols and Factors Influencing Outcome. J Clin Med. 2022; 11(3). PMC: 8836366. DOI: 10.3390/jcm11030737. View

18.

Kuo T, Lin C, Ho F . The soreness and numbness effect of acupuncture on skin blood flow. Am J Chin Med. 2004; 32(1):117-29. DOI: 10.1142/S0192415X04001825. View

19.

Inhorn M, Patrizio P . Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015; 21(4):411-26. DOI: 10.1093/humupd/dmv016. View

20.

Chu D, Fu L, Zhou W, Li Y . Effects of different open cryo-carriers on embryo survival and clinical outcome in frozen embryo transfer cycle patients. Syst Biol Reprod Med. 2018; 64(2):138-145. DOI: 10.1080/19396368.2017.1419510. View