Translation Inhibition Mediated by Interferon-Stimulated Genes During Viral Infections

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2024 Jul 27

PMID 39066259

Authors

Alexandria Smart

Orian Gilmer

Neva Caliskan

Affiliations

Soon will be listed here.

Abstract

Viruses often pose a significant threat to the host through the exploitation of cellular machineries for their own benefit. In the context of immune responses, myriad host factors are deployed to target viral RNAs and inhibit viral protein translation, ultimately hampering viral replication. Understanding how "non-self" RNAs interact with the host translation machinery and trigger immune responses would help in the development of treatment strategies for viral infections. In this review, we explore how interferon-stimulated gene products interact with viral RNA and the translation machinery in order to induce either global or targeted translation inhibition.

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