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The Antiviral Potential of : Advances and Perspectives

Overview
Journal Molecules
Publisher MDPI
Specialty Biology
Date 2024 Jul 27
PMID 39064906
Authors
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Abstract

Viruses pose a significant threat to human health, causing widespread diseases and impacting the global economy. , a traditional medicine and food homologous plant, is well known for its antiviral properties. This systematic review examines the antiviral potential of , including its antiviral activity, chemical structure and pharmacological parameters. Utilizing bioinformatics analysis, we revealed the correlation between and antiviral activity, identified overlaps between target genes and virus-related genes, and explored related signaling pathways. Moreover, a classified summary of the active components of , focusing on compounds associated with antiviral activity, provides important clues for optimizing the antiviral drug development of . Our findings indicate that showed a strong antiviral effect, and its active ingredients can effectively inhibit the replication and spread of a variety of viruses in this review. The antiviral mechanisms of may involve several pathways, including enhanced immune function, modulation of inflammatory responses, and inhibition of key enzyme activities such as viral replicase. These results underscore the potential antiviral application of as a natural plant and provide important implications for the development of new antiviral drugs.

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References
1.
Sanchez G, Aznar R . Evaluation of Natural Compounds of Plant Origin for Inactivation of Enteric Viruses. Food Environ Virol. 2015; . DOI: 10.1007/s12560-015-9181-9. View

2.
Ren Y, Nie L, Zhu S, Zhang X . Nanovesicles-Mediated Drug Delivery for Oral Bioavailability Enhancement. Int J Nanomedicine. 2022; 17:4861-4877. PMC: 9574265. DOI: 10.2147/IJN.S382192. View

3.
Parvez M, Alam P, Arbab A, Al-Dosari M, Alhowiriny T, Alqasoumi S . Analysis of antioxidative and antiviral biomarkers β-amyrin, β-sitosterol, lupeol, ursolic acid in leaves extract by validated HPTLC methods. Saudi Pharm J. 2018; 26(5):685-693. PMC: 6035322. DOI: 10.1016/j.jsps.2018.02.022. View

4.
Ulanowska M, Olas B . Biological Properties and Prospects for the Application of Eugenol-A Review. Int J Mol Sci. 2021; 22(7). PMC: 8036490. DOI: 10.3390/ijms22073671. View

5.
Kubica T, Alves S, Weiblen R, Lovato L . In vitro inhibition of the bovine viral diarrhoea virus by the essential oil of Ocimum basilicum (basil) and monoterpenes. Braz J Microbiol. 2014; 45(1):209-14. PMC: 4059298. DOI: 10.1590/S1517-83822014005000030. View