Nasopharyngeal Carcinoma Progression: Accumulating Genomic Instability and Persistent Epstein-Barr Virus Infection

Overview

Journal Curr Oncol

Publisher MDPI

Specialty Oncology

Date 2022 Sep 22

PMID 36135044

Authors

Xue Liu

Yayan Deng

Yujuan Huang

Jiaxiang Ye

Sifang Xie

Qian He

Yong Chen

Yan Lin

Rong Liang

Jiazhang Wei

Yongqiang Li

Jinyan Zhang

Affiliations

Soon will be listed here.

Abstract

Genomic instability facilitates the evolution of cells, tissues, organs, and species. The progression of human malignancies can be regarded as the accumulation of genomic instability, which confers a high evolutionary potential for tumor cells to adapt to continuous changes in the tumor microenvironment. Nasopharyngeal carcinoma (NPC) is a head-and-neck squamous-cell carcinoma closely associated with Epstein-Barr virus (EBV) infection. NPC progression is driven by a combination of accumulated genomic instability and persistent EBV infection. Here, we present a review of the key characteristics of genomic instability in NPC and the profound implications of EBV infection. We further discuss the significance of profiling genomic instability for the assessment of disease progression and treatment efficacy, as well as the opportunities and challenges of targeted therapies for NPC based on its unique genomic instability.

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