Preparation and Performance Evaluation of Polysaccharide-Iron Complex of

Overview

Journal Foods

Specialty Biotechnology

Date 2024 Jul 27

PMID 39063386

Authors

Mengpei Liu

Yan Wang

Rong Wang

Wei Zong

Lihua Zhang

Lu Wang

Affiliations

Soon will be listed here.

Abstract

An innovative iron supplement crucial for treating iron-deficiency anemia was developed in this study. Polysaccharide was extracted from leaves using a microwave-assisted hot water method, and subsequently, the polysaccharide-iron complex was synthesized through co-thermal synthesis with FeCl. The physicochemical properties, structure, and thermal stability of the complex were analyzed using FE-SEM, SEC-MALLS, FT-IR, XRD, and DSC techniques. Furthermore, the antioxidant activity of the polysaccharide-iron complex was evaluated through an experiment in vitro. The results revealed that the polysaccharide-iron complex had an iron content of 6.1% and an average particle size of 860.4 nm. The microstructure analysis indicated that the polysaccharide-iron complex possessed a flaky morphology with smooth and compact surfaces. Moreover, the formation of the Fe complex did not alter the structural framework of the polysaccharide; instead, it enhanced the polysaccharide's thermal stability. Compared to traditional iron supplements, the -derived polysaccharide-iron complex demonstrated significant antioxidant activity. Therefore, this novel compound exhibits significant potential as a viable iron supplement.

References

Yu S, Jiang J, Li W . Co-cultured and polysaccharide-iron(iii) chelates exhibit good antioxidant activity. RSC Adv. 2022; 10(46):27259-27265. PMC: 9055521. DOI: 10.1039/d0ra03258a. View

Shi S, Feng J, Liang Y, Sun H, Yang X, Su Z . Polysaccharide-Iron (III) Chelate as Peroxidase Mimics for Total Antioxidant Capacity Assay of Fruit and Vegetable Food. Foods. 2021; 10(11). PMC: 8623380. DOI: 10.3390/foods10112800. View

Zhang Y, Huang J, Sun M, Duan Y, Wang L, Yu N . Preparation, characterization, antioxidant and antianemia activities of polysaccharide iron (III) complex. Heliyon. 2023; 9(1):e12819. PMC: 9840143. DOI: 10.1016/j.heliyon.2023.e12819. View

Feng H, Fan J, Song Z, Du X, Chen Y, Wang J . Characterization and immunoenhancement activities of Eucommia ulmoides polysaccharides. Carbohydr Polym. 2015; 136:803-11. DOI: 10.1016/j.carbpol.2015.09.079. View

Zhang Z, Wang X, Han Z, Yin L, Zhao M, Yu S . Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC). Bioorg Med Chem Lett. 2011; 22(1):489-92. DOI: 10.1016/j.bmcl.2011.10.100. View

Liu Y, Sun Y, Huang G . Preparation and antioxidant activities of important traditional plant polysaccharides. Int J Biol Macromol. 2018; 111:780-786. DOI: 10.1016/j.ijbiomac.2018.01.086. View

Evans P, Rogers K, Dicken A, Godber S, Prokopiou D . X-ray diffraction tomography employing an annular beam. Opt Express. 2014; 22(10):11930-44. DOI: 10.1364/OE.22.011930. View

Xian H, Wang P, Jing H, Chen G, Cheng D, Ji F . Comparative study of components and anti-oxidative effects between sulfated polysaccharide and its iron complex. Int J Biol Macromol. 2018; 118(Pt A):1303-1309. DOI: 10.1016/j.ijbiomac.2018.04.177. View

Ganie S, Naik R, Ali A, Mir T, Mazumdar N . Preparation, characterization, release and antianemic studies of guar gum functionalized Iron complexes. Int J Biol Macromol. 2021; 183:1495-1504. DOI: 10.1016/j.ijbiomac.2021.05.125. View

10.

Jiang C, Xiong Q, Gan D, Jiao Y, Liu J, Ma L . Antioxidant activity and potential hepatoprotective effect of polysaccharides from Cyclina sinensis. Carbohydr Polym. 2012; 91(1):262-8. DOI: 10.1016/j.carbpol.2012.08.029. View

11.

Zhang J, Chen C, Fu X . Fructus mori L. polysaccharide-iron chelates formed by self-embedding with iron(iii) as the core exhibit good antioxidant activity. Food Funct. 2019; 10(6):3150-3160. DOI: 10.1039/c9fo00540d. View

12.

Jia N, Qiao H, Zhu W, Zhu M, Meng Q, Lu Q . Antioxidant, immunomodulatory, oxidative stress inhibitory and iron supplementation effect of Astragalus membranaceus polysaccharide-iron (III) complex on iron-deficiency anemia mouse model. Int J Biol Macromol. 2019; 132:213-221. DOI: 10.1016/j.ijbiomac.2019.03.196. View

13.

Yuan S, Dong P, Ma H, Liang S, Li L, Zhang X . Antioxidant and Biological Activities of the Lotus Root Polysaccharide-Iron (III) Complex. Molecules. 2022; 27(20). PMC: 9611182. DOI: 10.3390/molecules27207106. View

14.

Jing Y, Zhang S, Li M, Zhang R, Zhang H, Zheng Y . Structural characterization and biological activities of polysaccharide iron complex synthesized by plant polysaccharides: A review. Front Nutr. 2022; 9:1013067. PMC: 9561936. DOI: 10.3389/fnut.2022.1013067. View

15.

Jia Y, Li N, Wang Q, Zhou J, Liu J, Zhang M . Effect of Fe (III), Zn (II), and Cr (III) complexation on the physicochemical properties and bioactivities of corn silk polysaccharide. Int J Biol Macromol. 2021; 189:847-856. DOI: 10.1016/j.ijbiomac.2021.08.191. View

16.

Chen S, Guan X, Yong T, Gao X, Xiao C, Xie Y . Structural characterization and hepatoprotective activity of an acidic polysaccharide from . Food Chem X. 2022; 13:100204. PMC: 9039936. DOI: 10.1016/j.fochx.2022.100204. View

17.

Chi Y, Li Y, Zhang G, Gao Y, Ye H, Gao J . Effect of extraction techniques on properties of polysaccharides from Enteromorpha prolifera and their applicability in iron chelation. Carbohydr Polym. 2017; 181:616-623. DOI: 10.1016/j.carbpol.2017.11.104. View

18.

Wang J, Chen H, Wang Y, Xing L . Synthesis and characterization of a new Inonotus obliquus polysaccharide-iron(III) complex. Int J Biol Macromol. 2015; 75:210-7. DOI: 10.1016/j.ijbiomac.2015.01.041. View

19.

Tian X, Liang T, Liu Y, Ding G, Zhang F, Ma Z . Extraction, Structural Characterization, and Biological Functions of Polysaccharides: A Review. Biomolecules. 2019; 9(9). PMC: 6770593. DOI: 10.3390/biom9090389. View

20.

Cheng S, He F, Fu L, Zhang Y . Polysaccharide from rubescens: extraction, optimization, characterization and antioxidant activities. RSC Adv. 2022; 11(31):18974-18983. PMC: 9033498. DOI: 10.1039/d1ra01365c. View