Metabolomics and Biochemical Benefits of Multivitamin and Multimineral Supplementation in Healthy Individuals: A Pilot Study

Overview

Journal Foods

Specialty Biotechnology

Date 2024 Jul 27

PMID 39063291

Authors

Maria C Sanchez

Ana Herraiz

Maria J Ciudad

Marta Arias

Raquel Alonso

Carmen Doblas

Arancha Llama-Palacios

Luis Collado

Affiliations

Soon will be listed here.

Abstract

Scientific evidence regarding the effectiveness of vitamin and mineral supplements in healthy individuals remains scarce. In a randomized, double-blind study, 30 healthy individuals were assigned to receive a single daily dose of multivitamin and multimineral supplementation or a double daily dose for 30 days. Before and after the intake, an untargeted metabolomics assay for serum metabolites was conducted by hydrophilic interaction liquid chromatography-mass spectrometry, and clinical assessments of peripheral blood samples were performed. A paired -test for metabolic analysis, adjusted using the false discovery rate (FDR) and -value correction method (rate of change > 2 and FDR < 0.05), the Shapiro-Wilk test, Student's -test, and the Mann-Whitney U test were applied depending on the variable, with a 5% significance level. An impact on oxidative stress was observed, with a significant reduction in homocysteine levels and an increment of pyridoxic acid (vitamin B6). The effect on energy metabolism was shown by a significant increase in diverse metabolites, such as linoleoylcarnitine. Serum iron and calcium levels were also impacted. Overall, we observed a nutritional balance compatible with a good state of health. In conclusion, beneficial effects on adult health were demonstrated in relation to oxidative stress, energy metabolism, and nutritional balance.

References

Billman G . Homeostasis: The Underappreciated and Far Too Often Ignored Central Organizing Principle of Physiology. Front Physiol. 2020; 11:200. PMC: 7076167. DOI: 10.3389/fphys.2020.00200. View

Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D . The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF. Behav Brain Res. 2011; 220(2):271-80. DOI: 10.1016/j.bbr.2011.02.003. View

Serbina N, Jia T, Hohl T, Pamer E . Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol. 2008; 26:421-52. PMC: 2921669. DOI: 10.1146/annurev.immunol.26.021607.090326. View

Shenoy V, Mehendale V, Prabhu K, Shetty R, Rao P . Correlation of serum homocysteine levels with the severity of coronary artery disease. Indian J Clin Biochem. 2014; 29(3):339-44. PMC: 4062675. DOI: 10.1007/s12291-013-0373-5. View

McGarrah R, Crown S, Zhang G, Shah S, Newgard C . Cardiovascular Metabolomics. Circ Res. 2018; 122(9):1238-1258. PMC: 6029726. DOI: 10.1161/CIRCRESAHA.117.311002. View

Cros J, Cagnard N, Woollard K, Patey N, Zhang S, Senechal B . Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity. 2010; 33(3):375-86. PMC: 3063338. DOI: 10.1016/j.immuni.2010.08.012. View

Huang H, Caballero B, Chang S, Alberg A, Semba R, Schneyer C . The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference. Ann Intern Med. 2006; 145(5):372-85. DOI: 10.7326/0003-4819-145-5-200609050-00135. View

Zaric B, Obradovic M, Bajic V, Haidara M, Jovanovic M, Isenovic E . Homocysteine and Hyperhomocysteinaemia. Curr Med Chem. 2018; 26(16):2948-2961. DOI: 10.2174/0929867325666180313105949. View

Morine M, Monteiro J, Wise C, Teitel C, Pence L, Williams A . Genetic associations with micronutrient levels identified in immune and gastrointestinal networks. Genes Nutr. 2014; 9(4):408. PMC: 4169061. DOI: 10.1007/s12263-014-0408-4. View

10.

Oakley Jr G, Bell K, Weber M . Recommendations for accelerating global action to prevent folic acid-preventable birth defects and other folate-deficiency diseases: meeting of experts on preventing folic acid-preventable neural tube defects. Birth Defects Res A Clin Mol Teratol. 2004; 70(11):835-7. DOI: 10.1002/bdra.20058. View

11.

Tolouei Semnani R, Moore V, Bennuru S, McDonald-Fleming R, Ganesan S, Cotton R . Human monocyte subsets at homeostasis and their perturbation in numbers and function in filarial infection. Infect Immun. 2014; 82(11):4438-46. PMC: 4249311. DOI: 10.1128/IAI.01973-14. View

12.

Chiang J . Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol. 2003; 284(3):G349-56. DOI: 10.1152/ajpgi.00417.2002. View

13.

Kerner J, Hoppel C . Fatty acid import into mitochondria. Biochim Biophys Acta. 2000; 1486(1):1-17. DOI: 10.1016/s1388-1981(00)00044-5. View

14.

St-Pierre M, Kullak-Ublick G, Hagenbuch B, Meier P . Transport of bile acids in hepatic and non-hepatic tissues. J Exp Biol. 2001; 204(Pt 10):1673-86. DOI: 10.1242/jeb.204.10.1673. View

15.

Clarke R, Armitage J . Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Semin Thromb Hemost. 2000; 26(3):341-8. DOI: 10.1055/s-2000-8101. View

16.

Ozanska A, Szymczak D, Rybka J . Pattern of human monocyte subpopulations in health and disease. Scand J Immunol. 2020; 92(1):e12883. DOI: 10.1111/sji.12883. View

17.

Maggini S, Pierre A, Calder P . Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients. 2018; 10(10). PMC: 6212925. DOI: 10.3390/nu10101531. View

18.

Lane D, Richardson D . The active role of vitamin C in mammalian iron metabolism: much more than just enhanced iron absorption!. Free Radic Biol Med. 2014; 75:69-83. DOI: 10.1016/j.freeradbiomed.2014.07.007. View

19.

Pitts M, Hoffmann P . Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis. Cell Calcium. 2017; 70:76-86. PMC: 5671369. DOI: 10.1016/j.ceca.2017.05.001. View

20.

Heusschen L, Berendsen A, Cooiman M, Deden L, Hazebroek E, Aarts E . Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients. Obes Surg. 2021; 31(6):2520-2528. PMC: 8113195. DOI: 10.1007/s11695-021-05282-4. View