Electrochemical Impedance Spectroscopy in the Determination of the Dielectric Properties of Tau-441 Protein for Dielectrophoresis Response Prediction

Overview

Journal Bioengineering (Basel)

Date 2024 Jul 27

PMID 39061780

Authors

Zuriel Shee Da En

Ervina Efzan Mhd Noor

Aminuddin Ahmed Kayani

Mohd Hazwan Hussin

Mirza Farrukh Baig

Affiliations

Soon will be listed here.

Abstract

This study employs electrochemical impedance spectroscopy (EIS) to probe the behavior of Tau-441 protein, a key component implicated in Alzheimer's disease. Through meticulous experimentation and analysis, the impedance of Tau-441 protein suspension revealed a conductivity peak value of 1.02 S/m. The study demonstrates a high level of specificity and selectivity, particularly within the challenging nanomolar concentration range. Additionally, the EIS method enabled the prediction of Tau-441 protein's dielectrophoresis (DEP) response and the determination of the associated frequency range of 1 kHz to 1 MHz. These findings contribute to advancing our understanding of the molecular intricacies surrounding Tau-441 and hold promise for unraveling implications related to Alzheimer's disease. This study establishes a robust foundation for future research on neurodegenerative disease and biosciences, offering valuable insights into the electrochemical dynamics of Tau-441 protein.

Citing Articles

Electrochemical Technology for the Detection of Tau Proteins as a Biomarker of Alzheimer's Disease in Blood.

Wang J, Lu X, He Y Biosensors (Basel). 2025; 15(2).

PMID: 39996987 PMC: 11853436. DOI: 10.3390/bios15020085.

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