Expression of CD45 in Non-hematopoietic Cells: Implications in Regenerative Medicine and Disease Management

Overview

Journal Regen Med

Specialty Biotechnology

Date 2024 Jul 26

PMID 39058408

Authors

Madhurima Das

Prajakta Teli

Anuradha Vaidya

Vaijayanti Kale

Affiliations

Soon will be listed here.

Abstract

CD45 plays a crucial role in the regulation of hematopoiesis. However, a comprehensive understanding of its role in cells is lacking. Several tissue precursors express CD45, indicating its crucial role in tissue regeneration. These precursors would fall prey to the recent therapies involving CD45 as a target. CD45 double-positive tumor cells contribute to cancer progression, but whether CD45 is involved in the process needs to be investigated. Recently, we showed that aging induces CD45 expression in mesenchymal stromal cells and affects their differentiation potential. In this review, we, for the first time, unravel the important implications of the expression of CD45 in cells and provide novel insights into its potential therapeutic target in regenerative medicine and disease management.

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