Chromatin Assembly Factor 1 Suppresses Epigenetic Reprogramming Toward Adaptive Drug Resistance

Overview

Journal J Natl Cancer Cent

Specialty Oncology

Date 2024 Jul 22

PMID 39036786

Authors

Zhiquan Wang

Rentian Wu

Qian Nie

Kelly J Bouchonville

Robert B Diasio

Steven M Offer

Affiliations

Soon will be listed here.

Abstract

The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased chromatin accessibility is involved in adaptive BRAF inhibitor (BRAFi)-resistance in melanoma cells. We observed loss of chromatin assembly factor 1 (CAF-1) and its related histone H3 lysine 9 trimethylation (H3K9me3) with adaptive BRAFi resistance. We further showed that depletion of CAF-1 provides chromatin plasticity for effective reprogramming by AP1 components to promote BRAFi resistance. Our data suggest that therapeutic approaches to restore H3K9me3 levels may compensate for the loss of CAF-1 and, in turn, suppress resistance to BRAF inhibitors.

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