Current Understanding of Functional Peptides Encoded by LncRNA in Cancer

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2024 Jul 19

PMID 39030557

Authors

Hua Tian

Lu Tang

Zihan Yang

Yanxi Xiang

Qi Min

Mengshuang Yin

Huili You

Zhangang Xiao

Jing Shen

Affiliations

Soon will be listed here.

Abstract

Dysregulated gene expression and imbalance of transcriptional regulation are typical features of cancer. RNA always plays a key role in these processes. Human transcripts contain many RNAs without long open reading frames (ORF, > 100 aa) and that are more than 200 bp in length. They are usually regarded as long non-coding RNA (lncRNA) which play an important role in cancer regulation, including chromatin remodeling, transcriptional regulation, translational regulation and as miRNA sponges. With the advancement of ribosome profiling and sequencing technologies, increasing research evidence revealed that some ORFs in lncRNA can also encode peptides and participate in the regulation of multiple organ tumors, which undoubtedly opens a new chapter in the field of lncRNA and oncology research. In this review, we discuss the biological function of lncRNA in tumors, the current methods to evaluate their coding potential and the role of functional small peptides encoded by lncRNA in cancers. Investigating the small peptides encoded by lncRNA and understanding the regulatory mechanisms of these functional peptides may contribute to a deeper understanding of cancer and the development of new targeted anticancer therapies.

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