Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2024 Jul 17

PMID 39017844

Authors

Marc Pfefferle

Florence Vallelian

Affiliations

Soon will be listed here.

Abstract

NFE2-related factor 2 (NRF2) is a master transcription factor (TF) that coordinates key cellular homeostatic processes including antioxidative responses, autophagy, proteostasis, and metabolism. The emerging evidence underscores its significant role in modulating inflammatory and immune processes. This chapter delves into the role of NRF2 in myeloid cell differentiation and function and its implication in myeloid cell-driven diseases. In macrophages, NRF2 modulates cytokine production, phagocytosis, pathogen clearance, and metabolic adaptations. In dendritic cells (DCs), it affects maturation, cytokine production, and antigen presentation capabilities, while in neutrophils, NRF2 is involved in activation, migration, cytokine production, and NETosis. The discussion extends to how NRF2's regulatory actions pertain to a wide array of diseases, such as sepsis, various infectious diseases, cancer, wound healing, atherosclerosis, hemolytic conditions, pulmonary disorders, hemorrhagic events, and autoimmune diseases. The activation of NRF2 typically reduces inflammation, thereby modifying disease outcomes. This highlights the therapeutic potential of NRF2 modulation in treating myeloid cell-driven pathologies.

Citing Articles

Nrf2 Regulates Inflammation by Modulating Dendritic Cell-T Cell Crosstalk during Viral-Bacterial Superinfection.

Duray A, Miller L, Dresden B, Rago F, Antos D, McHugh K J Immunol. 2024; 213(12):1834-1843.

PMID: 39485002 PMC: 11611625. DOI: 10.4049/jimmunol.2400322.

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