Chikungunya Virus Release is Reduced by TIM-1 Receptors Through Binding of Envelope Phosphatidylserine

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2024 Jul 15

PMID 39007616

Authors

Judith M Reyes Ballista

Ashley J Hoover

Joseph T Noble

Marissa D Acciani

Kerri L Miazgowicz

Sarah A Harrison

Grace Andrea L Tabscott

Avery Duncan

Don N Barnes

Ariana R Jimenez

Melinda A Brindley

Affiliations

Soon will be listed here.

Abstract

Importance: Chikungunya virus (CHIKV) is an enveloped alphavirus transmitted by the bites of infectious mosquitoes. Infection with CHIKV results in the development of fever, joint pain, and arthralgia that can become chronic and last for months after infection. Prevention of this disease is still highly focused on vector control strategies. In December 2023, a new live attenuated vaccine against CHIKV was approved by the FDA. We aimed to study the cellular factors involved in CHIKV release, to better understand CHIKV's ability to efficiently infect and spread among a wide variety of cell lines. We found that TIM-1 receptors can significantly abrogate CHIKV's ability to efficiently exit infected cells. This information can be beneficial for maximizing viral particle production in laboratory settings and during vaccine manufacturing.

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