» Articles » PMID: 38997478

Fmoc Solid-Phase Peptide Synthesis

Overview
Specialty Molecular Biology
Date 2024 Jul 12
PMID 38997478
Authors
Affiliations
Soon will be listed here.
Abstract

Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. Here, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.

Citing Articles

Peptide-Based Biomaterials for Combatting Infections and Improving Drug Delivery.

Lombardi L, Li J, Williams D Pharmaceutics. 2024; 16(11).

PMID: 39598591 PMC: 11597775. DOI: 10.3390/pharmaceutics16111468.

References
1.
Sharma K, Sharma K, Sharma A, Jain R . Peptide-based drug discovery: Current status and recent advances. Drug Discov Today. 2022; 28(2):103464. DOI: 10.1016/j.drudis.2022.103464. View

2.
Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G . Therapeutic peptides: current applications and future directions. Signal Transduct Target Ther. 2022; 7(1):48. PMC: 8844085. DOI: 10.1038/s41392-022-00904-4. View

3.
Vadevoo S, Gurung S, Lee H, Gunassekaran G, Lee S, Yoon J . Peptides as multifunctional players in cancer therapy. Exp Mol Med. 2023; 55(6):1099-1109. PMC: 10318096. DOI: 10.1038/s12276-023-01016-x. View

4.
Li W, Separovic F, OBrien-Simpson N, Wade J . Chemically modified and conjugated antimicrobial peptides against superbugs. Chem Soc Rev. 2021; 50(8):4932-4973. DOI: 10.1039/d0cs01026j. View

5.
Trier N, Hansen P, Houen G . Peptides, Antibodies, Peptide Antibodies and More. Int J Mol Sci. 2019; 20(24). PMC: 6941022. DOI: 10.3390/ijms20246289. View