Recent Advances in Nanomaterials for the Treatment of Femoral Head Necrosis

Overview

Journal Hum Cell

Publisher Springer

Specialty Cell Biology

Date 2024 Jul 12

PMID 38995503

Authors

Yalin Yuan

Mi Zou

Shuqin Wu

Congcong Liu

Liang Hao

Affiliations

Soon will be listed here.

Abstract

Osteonecrosis of the femoral head (ONFH) is a condition that causes considerable pain and discomfort for patients, and its pathogenic mechanisms are not yet fully understood. While there have been many studies that suggest multiple factors may contribute to its development, current treatments involve both surgical and nonsurgical options. However, there is still much room for improvement in these treatment methods, particularly when it comes to preventing postoperative complications and optimizing surgical procedures. Nanomaterials, as a type of small molecule material, have shown great promise in treating bone tissue diseases, including ONFH. In fact, several nanocomposite materials have demonstrated specific effects in preventing ONFH, promoting bone tissue repair and growth, and optimizing surgical treatment. This article provides a comprehensive overview of current treatments for ONFH, including their advantages and limitations, and reviews the latest advances in nanomaterials for treating this condition. Additionally, this article explores the therapeutic mechanisms involved in using nanomaterials to treat ONFH and to identify new methods and ideas for improving outcomes for patients.

References

Zhao D, Zhang F, Wang B, Liu B, Li L, Kim S . Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J Orthop Translat. 2020; 21:100-110. PMC: 7152793. DOI: 10.1016/j.jot.2019.12.004. View

Hines J, Jo W, Cui Q, Mont M, Koo K, Cheng E . Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment. J Korean Med Sci. 2021; 36(24):e177. PMC: 8216992. DOI: 10.3346/jkms.2021.36.e177. View

Ohnaka K, Taniguchi H, Kawate H, Nawata H, Takayanagi R . Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis. Biochem Biophys Res Commun. 2004; 318(1):259-64. DOI: 10.1016/j.bbrc.2004.04.025. View

Yu H, Zhu D, Liu P, Yang Q, Gao J, Huang Y . Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol-induced osteonecrosis of the femoral head. J Cell Mol Med. 2020; 24(8):4439-4451. PMC: 7176840. DOI: 10.1111/jcmm.15103. View

Ng T, Ji J, Liu Q, Yao Y, Wang W, Cao Y . Evaluation of Myocilin Variant Protein Structures Modeled by AlphaFold2. Biomolecules. 2024; 14(1). PMC: 10813463. DOI: 10.3390/biom14010014. View

Zalavras C, Lieberman J . Osteonecrosis of the femoral head: evaluation and treatment. J Am Acad Orthop Surg. 2014; 22(7):455-64. DOI: 10.5435/JAAOS-22-07-455. View

Zhou W, Qu M, Lv Y, Zhu J . New Advances in Stem Cell Therapy for Osteonecrosis of the Femoral Head. Curr Stem Cell Res Ther. 2018; 14(3):226-229. DOI: 10.2174/1574888X13666181025120252. View

Petek D, Hannouche D, Suva D . Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment. EFORT Open Rev. 2019; 4(3):85-97. PMC: 6440301. DOI: 10.1302/2058-5241.4.180036. View

Cao F, Liu G, Wang W, Wang B, Wei X, Lu F . Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability. Biomed Res Int. 2017; 2017:1624074. PMC: 5671671. DOI: 10.1155/2017/1624074. View

10.

Liu B, Yang L, Wang B, Wang Z, Cheng L, Xie H . [Prevention for glucocorticoid-induced osteonecrosis of femoral head: a long-term clinical follow-up trail]. Zhonghua Yi Xue Za Zhi. 2017; 97(41):3213-3218. DOI: 10.3760/cma.j.issn.0376-2491.2017.41.004. View

11.

Yan Y, Pang Q, Xu R . Effects of erythropoietin for precaution of steroid-induced femoral head necrosis in rats. BMC Musculoskelet Disord. 2018; 19(1):282. PMC: 6081914. DOI: 10.1186/s12891-018-2208-2. View

12.

Kokabu S, Lowery J, Jimi E . Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells. Stem Cells Int. 2016; 2016:3753581. PMC: 4889852. DOI: 10.1155/2016/3753581. View

13.

Zhao L, Kaye A, Kaye A, Abd-Elsayed A . Stem Cell Therapy for Osteonecrosis of the Femoral Head: Current Trends and Comprehensive Review. Curr Pain Headache Rep. 2018; 22(6):41. DOI: 10.1007/s11916-018-0700-x. View

14.

Wang Y, Ma X, Chai W, Tian J . Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head. Stem Cells Int. 2019; 2019:8914569. PMC: 6341242. DOI: 10.1155/2019/8914569. View

15.

Chen C, Chang J, Lai K, Hou S, Chang C, Wang G . Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: a two-year multicenter, prospective, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2011; 64(5):1572-8. DOI: 10.1002/art.33498. View

16.

Salameh M, Moghamis I, Kokash O, Ahmed G . Hyperbaric oxygen therapy for the treatment of Steinberg I and II avascular necrosis of the femoral head: a report of fifteen cases and literature review. Int Orthop. 2021; 45(10):2519-2523. PMC: 8514350. DOI: 10.1007/s00264-021-05120-3. View

17.

Levin D, Norman D, Zinman C, Rubinstein L, Sabo E, Misselevich I . Treatment of experimental avascular necrosis of the femoral head with hyperbaric oxygen in rats: histological evaluation of the femoral heads during the early phase of the reparative process. Exp Mol Pathol. 1999; 67(2):99-108. DOI: 10.1006/exmp.1999.2273. View

18.

Goodman S . The biological basis for concentrated iliac crest aspirate to enhance core decompression in the treatment of osteonecrosis. Int Orthop. 2018; 42(7):1705-1709. DOI: 10.1007/s00264-018-3830-1. View

19.

Ciftci S, Gulec A, Mercan N, Yildrim A . A new complication of femur head core decompression surgery: compartment syndrome. J Pak Med Assoc. 2020; 70(9):1642-1644. DOI: 10.5455/JPMA.36021. View

20.

Hua K, Yang X, Feng J, Wang F, Yang L, Zhang H . The efficacy and safety of core decompression for the treatment of femoral head necrosis: a systematic review and meta-analysis. J Orthop Surg Res. 2019; 14(1):306. PMC: 6737645. DOI: 10.1186/s13018-019-1359-7. View